Abstract: Objective To study the indication of liver transplantation for the patients with previous extrahepatic malignancies. Methods 2 patients with hepatocelleuer carcinoma or liver cirrhosis,had suffered with rectal cancer and breast cancer, both of them had been receive radical surgery before, receiving orthotopic liver transplantation and postoperative treatment of individualize Immunosuppressive therapy, liver cancer patients after conventional chemotherapy. Results The patients recovered well after surgery, followed up for 79 months and 34 months, with good liver function, no tumor recurrence. Conclusion Previous extrahepatic malignancy should not be considered a contraindication for liver transplantation, selection of suitable patient and to take individual immunosuppressive and chemotherapy, can achieve satisfactory results.

Key words: Liver transplantation, previous extrahepatic malignancies, breast cancer, rectal cancer