Abstract: Abstract：Objective To investigate the effect of TRAIL on CIA mice and its possible mechanism. Methods CIA was induced in DBA/1J mice with bovine type II collagen and Freund’s adjuvant. AAV-TRAIL particles were injected intra-articularly into knee joints of the mice. Th1/Th2 cytokines were detected by CBA method. Results The intra-articular injection of AAV-TRAIL reduced the severity of joint swelling in the CIA mice. And TRAIL inhibited Th1 cytokines release of splenocyte from CIA mice, but did not influence Th2 cytokines release. Conclusion TRAIL inhibited Th1 cytokines release was perhaps involved in anti-arthritis effect of TRAIL.

Key words: Rheumatoid Arthritis (RA), Collagen-induced arthritis (CIA) mice, TRAIL, Th1 cytokine, Th2 cytokine