脂联素基因+45位T/G多态性与2型糖尿病遗传易感性的相关性

基础医学与临床 ›› 2008, Vol. 28 ›› Issue (9): 940-943.

脂联素基因+45位T/G多态性与2型糖尿病遗传易感性的相关性

魏颖丽何兰杰霍正浩赵巍

浙江武警总队医院杭州医院宁夏医学院附属医院内分泌科宁夏医学院宁夏医学院医学遗传学与细胞生物学教研室

收稿日期:2006-04-05 修回日期:2008-01-30 出版日期:2008-09-25 发布日期:2008-09-25
通讯作者: 霍正浩

SNP 45(T/G) of adiponectin gene polymorphism and genetic susceptibility to type 2 diabetes mellitus

Ying-li WEI, Lan-jie HE, Zheng-hao HUO, Wei ZHAO

Zhejiang Provincial Crops Hospital, Chinese People's Armed Police Forces Ningxia Medical College

Received:2006-04-05 Revised:2008-01-30 Online:2008-09-25 Published:2008-09-25
Contact: Zheng-hao HUO,

摘要/Abstract

摘要： 目的：研究脂联素基因单核苷酸多态性（SNP）45（T/G）位点与宁夏汉族人群2型糖尿病之间的关系。方法：选择100例2型糖尿病患者和101例正常对照者，采用聚合酶链式反应一限制性内切酶长度多态性(PCR-RFLP)技术，对脂联素基因SNP45多态性位点进行基因分型同时测定代谢参数。结果：2型糖尿病组SNP45位点GG基因型频率和G等位基因频率均高于正常对照组(分别为13% vs 3%；76% vs 24%，均P<0.05)。结论：脂联素基因的SNP45多态性位点与宁夏汉族人群中2型糖尿病相关，GG基因型者具有2型糖尿病高易感性。

Abstract: Objective To investigate the association of single nucleotide polymorphisms (SNP)45T/G in the adiponectin gene with type 2 diabetes of Han nationality in Ningxia.. Methods PCR- RFLP method was used to determine the distributions of alleles and genotypes frequencies of SNP45T/G polymorphisms in adiponectin gene in 100 type 2 diabetic patients and 101 normal subjects .Results The distribution of both genotypes and alleles frequencies of the SNP45 polymorphisms were significantly different between two groups(GG genotype:13% vs 3% ,P<0.05;G allele;76% vs 24%, P<0.05). Conclusion The results suggest that SNP45 in adiponectin gene was associated with type 2 diabetes of Han nationality in Ningxia. Individuals with SNP45 GG genotypes of adiponectin gene have high susceptibility to type 2 diabetes.

魏颖丽何兰杰霍正浩赵巍. 脂联素基因+45位T/G多态性与2型糖尿病遗传易感性的相关性[J]. 基础医学与临床, 2008, 28(9): 940-943.

Ying-li WEI; Lan-jie HE; Zheng-hao HUO; Wei ZHAO. SNP 45(T/G) of adiponectin gene polymorphism and genetic susceptibility to type 2 diabetes mellitus[J]. Basic & Clinical Medicine, 2008, 28(9): 940-943.