关键词: 血管紧张素转换酶基因, 原发性高血压, 基因多态性, 血脂

Abstract: Objective To study the relationship between angiotensin converting enzyme(ACE) gene dyslipemia and Essential Hypertension.Methods To examinate the I/D Polymorphism of ACE gene by PCR .Biochemical indexex included of TC、TG、HDL、LDL and VLDL were detected by autochiemical emalyzer. Results The HDL was higher in II type than the others; The LDL was higher in ID、DD types than the II type.The morbidities of EH were different among three gene types, the morbidity of EH was higher in ID (19.88%)、DD (20.82%) types than the II (14.26%) type(p<0.05);There was a significant difference in the distribution of ACE genetypes and allele frequency in different cohort who were EH or not (P<0.05,P<0.01).The lipemia was different between EH group and NEH group,except HDL ,and LDL in ID、II genetypes.In NEH group,the TC was higher in II type than the DD type;The LDL was higher in ID、DD types than the II type. Conclusion The morbidity of EH were different among three gene types.Polymorphism of ACE gene has some relation of lipemia levels such as TC、HDL、LDH .

Key words: angiotensin converting enzyme, essential hypertension, genetic polymorphism, Plasma Lipid