血清C反应蛋白在大鼠慢性牙周炎合并动脉粥样硬化模型中的表达

基础医学与临床 ›› 2009, Vol. 29 ›› Issue (2): 124-128.

血清C反应蛋白在大鼠慢性牙周炎合并动脉粥样硬化模型中的表达

倪佳张源明徐隽钟良军史芳川周晓欢

新疆医科大学第一附属医院口腔科新疆医科大学第一附属医院心脏中心新疆医科大学第一附属医院口腔科

收稿日期:2008-12-22 修回日期:2008-12-25 出版日期:2009-02-25 发布日期:2009-02-25
通讯作者: 钟良军

Detection of CRP level in rats chronic periodontal and atherosclerosis compound model

Jia NI, Yuan-ming ZHANG, Jun XU, Liang-jun ZHONG, Fang-chuan SHI, Xiao-huan ZHOU

Dept. of Stomatology，,The First Teaching Hospital, Xinjiang Medical University Dept. of Cardiology,The First Teaching Hospital, Xinjiang Medical University Dept. of Stomatology，,The First Teaching Hospital, Xinjiang Medical University

Received:2008-12-22 Revised:2008-12-25 Online:2009-02-25 Published:2009-02-25
Contact: Liang-jun ZHONG,

摘要/Abstract

摘要： 目的检测和分析大鼠慢性牙周炎（CP）合并动脉粥样硬化（As）模型中血清C反应蛋白（CRP）的表达。方法 60只Wistar大鼠随机分为4组，每组15只，A：正常对照组，B：CP组，C：As组，D：CP+As组，各组接受相应的建模处理。观察牙周组织及动脉血管病理改变，酶联免疫吸附法（ELISA）检测血清CRP水平。结果牙周病理学观察：B、D组实验牙牙周炎症表现明显，附着丧失（AL）水平较A、C组有明显增加（P<0.05）。动脉病理学观察：C、D组主动脉及胸、腹主动脉形成粥样硬化病变。D组血清CRP水平高于其他组（P<0.05）。相关性分析显示：B、D组CRP与AL均呈正相关。结论 CP与As可能相互影响、促进，两疾病的发生发展与血清CRP水平有关。

Abstract: Objective To detect and analyse CRP level in rats chronic periodontal and atherosclerosis compound model. Methods 60 rats were randomly divided into four groups, each group 15: Group A:control group; Group B:periodontitis group; Group C:atherosclerosis group;Group D:periodontitis and atherosclerosis group. Every group accepts the corresponding treatment. Observe pathological changes in periodontal tissue of experimental teeth and arterial vessels. CRP level in serum were assayed by ELISA. Results Histopathology Observation of periodontal tissue revealed: Obvious inflammation of periodontal tissue were observed in group B,D. Attachment loss level in group B and D were higher than that of A, C groups(P <0.05). Histopathology Observation of arteries revealed: tunica media of artery thickening in group B. Thoracic aorta, abdominal aorta atherosclerotic lesions formationed in group C,D. Serum levels of CRP in group D were higher than other groups (P <0.05). Dependablity analyse revealed: CRP and AL in both group B and D were positive correlation. Conclusion Atherosclerosis and periodontitis could influence each other,the development of two diseases may concerned with serum levels of CRP.

倪佳张源明徐隽钟良军史芳川周晓欢. 血清C反应蛋白在大鼠慢性牙周炎合并动脉粥样硬化模型中的表达[J]. 基础医学与临床, 2009, 29(2): 124-128.

Jia NI; Yuan-ming ZHANG; Jun XU; Liang-jun ZHONG; Fang-chuan SHI; Xiao-huan ZHOU. Detection of CRP level in rats chronic periodontal and atherosclerosis compound model[J]. Basic & Clinical Medicine, 2009, 29(2): 124-128.