β-NGF和p75NTR在鼠胚触须隆突区的表达

基础医学与临床 ›› 2008, Vol. 28 ›› Issue (6): 539-542.

β-NGF和p75NTR在鼠胚触须隆突区的表达

林森连小华李婷婷金旻王韵杨恬

成都医学院人体解剖与组织胚胎学教研室第三军医大学细胞生物学教研室成都医学院药物分析教研室第三军医大学大坪附属医院创伤实验室第三军医大学细胞生物学教研室

收稿日期:2007-05-23 修回日期:2007-07-16 出版日期:2008-06-25 发布日期:2008-06-25

Expression of β-NGF and p75NTR in vibrissa follicle bulge of developingr rat embryo

Sen LIN, Xiao-hua LIAN, Ting-ting LI, Min JIN, Yun WANG, Tian YANG

Dept. of Anatomy and Histo-embryology, Chengdu Medical College

Received:2007-05-23 Revised:2007-07-16 Online:2008-06-25 Published:2008-06-25

摘要/Abstract

摘要： 目的研究胚胎大鼠触须毛囊隆突区β-NGF和p75NTR与毛囊干细胞特异标志物的表达规律。方法使用冰冻超薄切片，免疫组织化学染色方法和统计分析。结果胚胎大鼠的触须隆突区表达的β-NGF和p75NTR呈规律性变化。3种毛囊干细胞（HFSC）标志物的表达有差异，毛囊发生初期毛囊干细胞（HFSC）不仅仅定位于触须毛囊上段，整个毛囊下部3/4都有表达。结论 β-NGF和p75NTR的表达变化可能与毛囊干细胞以及毛囊的生物学特性有关。

关键词: 大鼠胚胎, 触须毛囊, β-NGF, p75NTR

Abstract: Object To detect the expression of β-NGF, p75NTR and hair follicle stem cell specific markers in vibrissa hair follicle of developing rat embryo. Methods Using frozen section and Immunohistochemistry to detect the expression of β-NGF and p75NTR, finally analysis data. Results The expressions of β-NGF and p75NTR in rat embryo vibrissa follicle change regularly. The expressions of three stem cell markers were different. Hair follicle stem cells (HFSCs) not only located in upper-hair follicle, but also in 3/4 of the lower part of the hair follicle in early stage of hair follicle morphogenesis. Conclusion The expression of β-NGF and p75NTR may be correlated with characteristics of hair follicle and hair follicle stem cells.

Key words: Rat embryo, Hair follicle, β-NGF, p75NTR

林森连小华李婷婷金旻王韵杨恬. β-NGF和p75NTR在鼠胚触须隆突区的表达[J]. 基础医学与临床, 2008, 28(6): 539-542.

Sen LIN; Xiao-hua LIAN; Ting-ting LI; Min JIN; Yun WANG; Tian YANG. Expression of β-NGF and p75NTR in vibrissa follicle bulge of developingr rat embryo[J]. Basic & Clinical Medicine, 2008, 28(6): 539-542.