社区相关性耐甲氧西林金黄色葡萄球菌致病性研究进展

基础医学与临床 ›› 2009, Vol. 29 ›› Issue (6): 657-660.

社区相关性耐甲氧西林金黄色葡萄球菌致病性研究进展

周与华李擎天郭晓奎

上海交通大学医学院基础医学院

收稿日期:2008-05-28 修回日期:2008-08-31 出版日期:2009-06-25 发布日期:2009-06-25

Recent research of the virulence of community-associated methicillin-resistant Staphylococcus aurues

Yu-hua ZHOU, Qing-tian LI, Xiao-kui GUO

Institutes of Medical Sciences，Shanghai Jiao Tong University School of Medicine

Received:2008-05-28 Revised:2008-08-31 Online:2009-06-25 Published:2009-06-25

摘要/Abstract

摘要： 社区相关性耐甲氧西林金黄色葡萄球菌(CA-MRSA)自从上世纪八十年代出现以来，得到了全世界的普遍关注。CA-MRSA较强地适应外界环境的能力和定植能力对于其致病性起到了十分重要的作用，近期在CA-MRSA-USA300型菌株的基因组中发现的可移动精氨酸代谢元件(ACME)，以及该段DNA编码的精氨酸脱亚胺酶(arginine deiminase)对MRSA在人体中的定植起到了重要作用。

关键词: 金黄色葡萄球菌, 耐甲氧西林, 社区相关性

Abstract: After the emergence in 1980s, community-associated methicillin-resistant Staphylococcus aurues (CA-MRSA) has caught great attention of the researchers and clinical practitioners all over the world. In recent researching papers, people found that CA-MRSA's abilities to adapt itself to the hostile environment and to colonize is a kind of important virulence factor. A newly unveiled gene, designated arginine catabolic mobile element (ACME), in USA300 stains contributes much to this sort of ability. The arginine deiminase encoded by ACME plays an important role in colonization.

Key words: Staphylococcus aurues, methicillin-resistant, community-associated

周与华李擎天郭晓奎. 社区相关性耐甲氧西林金黄色葡萄球菌致病性研究进展[J]. 基础医学与临床, 2009, 29(6): 657-660.

Yu-hua ZHOU; Qing-tian LI; Xiao-kui GUO. Recent research of the virulence of community-associated methicillin-resistant Staphylococcus aurues[J]. Basic & Clinical Medicine, 2009, 29(6): 657-660.