CALCOCO1与恶性肿瘤的发生发展

doi:10.16352/j.issn.1001-6325.2023.11.1733

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (11): 1733-1737.doi: 10.16352/j.issn.1001-6325.2023.11.1733

CALCOCO1与恶性肿瘤的发生发展

贾楠, 王志莲^*

山西医科大学第二医院妇产科,山西太原 030000

收稿日期:2022-11-24 修回日期:2023-06-01 出版日期:2023-11-05 发布日期:2023-10-30
通讯作者: ^*ZL2009wang@163.com

CALCOCO1 in the progression of malignant tumors

JIA Nan, WANG Zhilian^*

Department of Obstetrics and Gynecology, the Second Hospital of Shanxi Medical University, Taiyuan 030000, China

Received:2022-11-24 Revised:2023-06-01 Online:2023-11-05 Published:2023-10-30
Contact: ^*ZL2009wang@163.com

摘要/Abstract

摘要： 钙结合和螺旋结构域 1(CALCOCO1)是近年来新发现的一种自噬调节蛋白,其在选择性自噬中有重要作用。编码基因CALCOCO1位于12q13.13,其编码的CALCOCO1蛋白,通过与ATG8家族蛋白结合,锚定于内质网及高尔基体上,参与内质网及高尔基体自噬,从而参与选择性自噬和早期阶段的自噬体形成。当mTOR通路被激活后,mTOR可通过自噬依赖途径调节CALCOCO1的表达。CALCOCO1在恶性肿瘤的发生、转移及治疗等方面都发挥作用。

关键词: 自噬, 钙结合和螺旋结构域 1(CALCOCO1), 自噬相关蛋白8家族(ATG8), 哺乳动物雷帕霉素靶蛋白(mTOR), 肿瘤

Abstract: Calcium binding and coiled-coil domain 1 (CALCOCO1) is an autophagy regulatory protein being discovered in recent years, which plays an important role in selective autophagy process. The gene coding for autophagy is located at 12q13.13, and its coding protein is CALCOCO1 protein. Which functions by binding to ATG8 family proteins, it anchors to the endoplasmic reticulum and the Golgi apparatus and thus initiate the autophagy of endoplasmic reticulum and Golgi aparatus, and thereby participating in selective autophagy and early stages of autophagosome formation. When the mTOR pathway is activated, mTOR regulates the expression of CALCOCO1 through the autophagy-dependent pathway. CALCOCO1 plays a role in the occurrence and metastasis, and so is a potential target for chemotherapy of malignant tumors.

Key words: autophagy, calcium binding and coiled-coil domain 1 (CALCOCO1), autophagy-related protein 8 family (ATG8), mammalian target of rapamycin (mTOR), tumor

中图分类号:

贾楠, 王志莲. CALCOCO1与恶性肿瘤的发生发展[J]. 基础医学与临床, 2023, 43(11): 1733-1737.

JIA Nan, WANG Zhilian. CALCOCO1 in the progression of malignant tumors[J]. Basic & Clinical Medicine, 2023, 43(11): 1733-1737.

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CALCOCO1与恶性肿瘤的发生发展

CALCOCO1 in the progression of malignant tumors

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