内质网应激在低氧性肺动脉高压中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.05.0848

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (5): 848-851.doi: 10.16352/j.issn.1001-6325.2023.05.0848

内质网应激在低氧性肺动脉高压中作用的研究进展

刘幸幸, 王威威^*, 袁好鑫

哈尔滨医科大学附属第二医院麻醉科,黑龙江哈尔滨 150086

收稿日期:2022-04-20 修回日期:2022-06-29 出版日期:2023-05-05 发布日期:2023-04-26
通讯作者: ^*wangweiwei_1980@126.com

Research progress of endoplasmic reticulum stress of hypoxic pulmonary hypertension

LIU Xingxing, WANG Weiwei^*, YUAN Haoxin

Department of Anesthesiology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China

Received:2022-04-20 Revised:2022-06-29 Online:2023-05-05 Published:2023-04-26
Contact: ^*wangweiwei_1980@126.com

摘要/Abstract

摘要： 低氧性肺动脉高压(HPH)是长期低氧导致的血管持续性收缩和血管不可逆重塑的严重肺部并发症。低氧可干扰内质网腔内蛋白质折叠过程,激活内质网应激(ERS)。ERS作为细胞应激的核心反应,与HPH的发生发展关系密切。

关键词: 低氧性肺动脉高压, 内质网应激, 未折叠蛋白反应

Abstract: Hypoxic pulmonary hypertension (HPH) is a serious complication caused by long-term hypoxia,which is characterized by persistent vasoconstriction and irreversible vascular remodeling. The hypoxia may destroy protein folding process in endoplasmic reticulum and activate endoplasmic reticulum stress(ERS). As the core response of cell stress, ERS is closely related to the development of HPH.

Key words: hypoxic pulmonary hypertension, endoplasmic reticulum stress, unfolded protein response

中图分类号:

刘幸幸, 王威威, 袁好鑫. 内质网应激在低氧性肺动脉高压中作用的研究进展[J]. 基础医学与临床, 2023, 43(5): 848-851.

LIU Xingxing, WANG Weiwei, YUAN Haoxin. Research progress of endoplasmic reticulum stress of hypoxic pulmonary hypertension[J]. Basic & Clinical Medicine, 2023, 43(5): 848-851.

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内质网应激在低氧性肺动脉高压中作用的研究进展

Research progress of endoplasmic reticulum stress of hypoxic pulmonary hypertension

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