胃内微生态在胃癌发生过程中作用的研究进展

doi:10.16352/j.issn.1001-6325.2022.12.1960

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (12): 1960-1964.doi: 10.16352/j.issn.1001-6325.2022.12.1960

胃内微生态在胃癌发生过程中作用的研究进展

纪若愚^#, 曹馨元^#, 张亦臻, 王强, 吴晰, 杨莹韵^*, 杨爱明^*

中国医学科学院北京协和医学院北京协和医院消化内科,北京 100730

收稿日期:2021-07-28 修回日期:2022-01-07 出版日期:2022-12-05 发布日期:2022-11-23
通讯作者: ^* yangyingyun@pumch.cn; yangam2020@126.com
作者简介:^#对本文有相同贡献
基金资助:
北京协和医院青年科研基金(PUMCH201911356)

Research progress on the role of gastric microecology in gastric carcinogenesis

JI Ruo-yu^#, CAO Xin-yuan^#, ZHANG Yi-zhen, WANG Qiang, WU Xi, YANG Ying-yun^*, YANG Ai-ming^*

Department of Gastroenterology, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730, China

Received:2021-07-28 Revised:2022-01-07 Online:2022-12-05 Published:2022-11-23
Contact: ^* yangyingyun@pumch.cn; yangam2020@126.com

摘要/Abstract

摘要： 胃内存在独特的微生态系统,其稳态的破坏与胃癌的发生密切相关。胃癌的发生伴随着胃黏膜菌群失调,表现为菌群多样性下降和菌群构成改变。菌群失调则进一步诱发胃内代谢环境的紊乱,驱动了有助于胃癌发生和发展的肿瘤微环境的形成。探究胃内微生态参与胃癌发生的作用机制有利于为胃癌的诊断和治疗提供新思路。

关键词: 胃微生态, 胃癌, 菌群失调

Abstract: Human stomach has a unique microbial ecosystem, and the disruption of its homeostasis is closely associated with the development of gastric cancer (GC). Gastric carcinogenesis is correlated with the dysbiosis of gastric mucosal microbiota, which is characterized by the decrease of biologigical diversity and alterations of the composition. The microbiota dysbiosis further induces metabolic disorders and triggers the formation of tumor microenvironment in the stomach which contributes to the development and progression of GC. Exploring the role of gastric micro-ecology in gastric carcinogenesis may provide new insights into the diagnosis and treatment for GC.

Key words: gastric microbiota, gastric cancer, microbiota dysbiosis

中图分类号:

纪若愚, 曹馨元, 张亦臻, 王强, 吴晰, 杨莹韵, 杨爱明. 胃内微生态在胃癌发生过程中作用的研究进展[J]. 基础医学与临床, 2022, 42(12): 1960-1964.

JI Ruo-yu, CAO Xin-yuan, ZHANG Yi-zhen, WANG Qiang, WU Xi, YANG Ying-yun, YANG Ai-ming. Research progress on the role of gastric microecology in gastric carcinogenesis[J]. Basic & Clinical Medicine, 2022, 42(12): 1960-1964.

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胃内微生态在胃癌发生过程中作用的研究进展

Research progress on the role of gastric microecology in gastric carcinogenesis

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