透明质酸敷料促进Picoway激光术后皮肤屏障的修复

doi:10.16352/j.issn.1001-6325.2022.12.1916

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (12): 1916-1920.doi: 10.16352/j.issn.1001-6325.2022.12.1916

透明质酸敷料促进Picoway激光术后皮肤屏障的修复

陈凤娟¹, 柯锦², 钱丽洁¹, 马委委¹, 王雄^1*

1.上海交通大学医学院附属第六人民医院皮肤科,上海 200233;
2.复旦大学附属浦东医院皮肤科,上海 201399

收稿日期:2022-09-06 修回日期:2022-10-21 出版日期:2022-12-05 发布日期:2022-11-23
通讯作者: ^* xiongw89@sina.com
基金资助:
上海市卫健委中医药科研项目(2020LP006)

Hyaluronic acid medical dressing promotes skin barrier repair after Picoway laser treatment

CHEN Feng-juan¹, KE Jin², QIAN Li-jie¹, MA Wei-wei¹, WANG Xiong^1*

1. Department of Dermatology,the Sixth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200233;
2. Department of Dermatology,Pudong Hospital Affiliated to Fudan University,Shanghai 201399,China

Received:2022-09-06 Revised:2022-10-21 Online:2022-12-05 Published:2022-11-23
Contact: ^* xiongw89@sina.com

摘要/Abstract

摘要： 目的研究透明质酸医用创面敷料在超皮秒(Picoway)激光术后对皮肤屏障修复的有效性和安全性。方法招募了30例面部接受激光术后的受试者,随机分为试验组和对照组。试验组治疗后即刻给予医用创面敷料和上海市皮肤病医院自制的单乳膏修护皮肤,对照组只给予单乳膏,连续使用7 d。结果皮肤图像分析仪(VISIA-6)定量检测结果显示,与对照组相比,激光治疗后7 d试验组的红色区、棕色斑和纹理明显改善(P＜0.05);CK皮肤测试仪(MPA-580)检测结果显示,在激光治疗后不同时间点,试验组皮肤含水量明显高于对照组,各时间点经皮水分丢失明显低于对照组(P＜0.05)。30例受试者未出现严重不良反应。结论透明质酸医用创面敷料能促进Picoway激光术后皮肤屏障修复。

关键词: 透明质酸, Picoway激光, 皮肤屏障

Abstract: Objective To study the efficacy and safety of hyaluronic acid medical wound dressing on skin repair after Picoway laser treatment. Methods Thirty patients after Picoway laser treatment were randomly divided into medical wound dressing group and control group. Medical wound dressing group was treated with medical wound dressing combined with the Danrushuang made by Shanghai Dermatology Hospital immediately after treatment, while the control group was treated with the Danrushuang made by Shanghai Dermatology Hospital alone for 7 days. Results The quantitative evaluation results of skin image analyzer (VISIA-6) showed that the improvement of redness area, texture and brown spots in the medical wound dressing group was better than that in the control group(P＜0.05) after 7 days treatment. CK skin tester (MPA-580) showed that the skin water content of the medical wound dressing group was obviously higher than that of the control group at different time points after laser treatment, and the transepidermal water loss at each time point was significantly lower than that of the control group(P＜0.05). There was no significant adverse events recorded in all patients. Conclusions The use of hyaluronic acid medical wound dressing after Picoway laser treatment may promote the recovery of the skin barrier, alleviate acute inflammatory reaction and have an obvious moisturizing effect.

Key words: hyaluronic acid, Picoway laser, skin barrier

中图分类号:

R751

陈凤娟, 柯锦, 钱丽洁, 马委委, 王雄. 透明质酸敷料促进Picoway激光术后皮肤屏障的修复[J]. 基础医学与临床, 2022, 42(12): 1916-1920.

CHEN Feng-juan, KE Jin, QIAN Li-jie, MA Wei-wei, WANG Xiong. Hyaluronic acid medical dressing promotes skin barrier repair after Picoway laser treatment[J]. Basic & Clinical Medicine, 2022, 42(12): 1916-1920.

参考文献 13

[1]	Chan JC,Shek SY,Kono T, et al. A retrospective analysis on the management of pigmented lesions using a picose-cond 755-nm alexandrite laser in Asians[J]. Lasers Surg Med,2016,48: 23-29.
[2]	Bukhari SNA,Roswandi NL,Waqas M,et al. Hyaluronic acid, a promising skin rejuvenating biomedicine: a review of recent updates and pre-clinical and clinical investiga-tions on cosmetic and nutricosmetic effects[J]. Int J Biol Macromol, 2018,120: 1682-1695.
[3]	Beasley KL,Weiss MA,Weiss RA. Hyaluronic acid fillers:a comprehensive review[J]. Facial Plast Surg,2009,25:86-94.
[4]	朱文驿,邓小锋,孟宏,等. 透明质酸在化妆品中的应用[J]. 中国化妆品,2016,24:72-74.
[5]	Ahn KJ,Zheng Z,Kwon TR,et al. Pattern analysis of laser-tattoo interactions for pico-second- and nanosecond-domain 1,064-nm neodymium-doped yttrium-aluminum-garnet lasers in tissue-mimicking phantom[J]. Sci Rep,2017,7:1533-1542.
[6]	Freedman JR,Kaufman J,Metelitsa AL,et al. Picosecond lasers: the next generation o-f short-pulsed lasers[J]. Semin Cutan Med Surg,2014,33: 164-168.
[7]	马骁. 透明质酸钠和胶原蛋白在激光术后皮肤护理品中的应用研究[D]. 上海:复旦大学,2013:41-49.
[8]	杨蓉娅,陈瑾. 黄褐斑光电治疗与修复专家共识[J]. 实用皮肤病学杂志,2020,13: 65-73.
[9]	邹道佩, 蒲以欢, 陈阳美,等. 神经酰胺喷剂在强脉冲光嫩肤术后皮肤修复中的疗效观察[J]. 中国美容医学杂志,2019,28:40-43.
[10]	苏译旻,王焱,林彤. 透明质酸在皮肤科的应用[J]. 中国麻风皮肤病杂志,2018,34: 314-320.
[11]	刘付华,何黎,顾华. 主要含透明质酸的生物贴膜抑制BALB/c小鼠AD模型炎症反应及恢复其皮肤屏障功能的实验研究[J]. 皮肤病与性病,2021,43: 609-616.
[12]	Yoshihara T,Shimada K,Momoi Y,et al. A new method of measuring the transepidermal water loss (TEWL) of dog skin[J]. J Vet Med Sci,2007,69: 289-292.
[13]	张慧,俞冰,牛峰,等. 注射用透明质酸钠在面部美容外科中的应用观察[J]. 中华口腔医学杂志,2017,52: 194-197.

透明质酸敷料促进Picoway激光术后皮肤屏障的修复

Hyaluronic acid medical dressing promotes skin barrier repair after Picoway laser treatment

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 13

相关文章 1

编辑推荐

Metrics

本文评价