铁死亡在阿尔茨海默病中作用的研究进展

doi:10.16352/j.issn.1001-6325.2022.07.1129

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (7): 1129-1133.doi: 10.16352/j.issn.1001-6325.2022.07.1129

铁死亡在阿尔茨海默病中作用的研究进展

徐娟, 李晔^*

昆明理工大学医学院, 云南昆明 650500

收稿日期:2021-10-28 修回日期:2022-05-07 出版日期:2022-07-05 发布日期:2022-06-29
通讯作者: * liye918@gmail.com
基金资助:
国家自然科学基金(81460167);云南省教育厅科学研究基金(2019J0041);云南省万人计划“青年拔尖人才”专项(YNWR-QNBJ-2018-126)

Research progress on the role of ferroptosis in Alzheimer's disease

XU Juan, LI Ye^*

School of Medicine, Kunming University of Science and Technology, Kunming 650500, China

Received:2021-10-28 Revised:2022-05-07 Online:2022-07-05 Published:2022-06-29
Contact: * liye918@gmail.com

摘要/Abstract

摘要： 阿尔茨海默病(AD)是老年人中最高发的神经退行性疾病。AD患者表现出来的进行性神经元丢失和死亡,及与脑铁异常水平相关的高氧化应激等症状,可能与铁死亡这种新型细胞死亡方式相关。铁死亡的两大特征,铁稳态失调和脂质过氧化可以将铁死亡和AD联系起来。铁死亡或许能为AD治疗提供一些新思路。

关键词: 阿尔茨海默病(AD), 铁死亡, 铁稳态失调, 脂质过氧化

Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly. The symptoms of progressive neuronal loss and death in AD, as well as the hyper-oxidative stress associated with abnormal brain iron levels, may be related to ferroptosis, a new way of cell death. Two characteristics of ferroptosis, iron homeostasis and lipid peroxidation, may potentially link ferroptosis to AD. The research on potential role of ferroptosis may provide new ideas for the treatment of AD.

Key words: Alzheimer's disease(AD), ferroptosis, iron homeostasis disorder, lipid peroxidation

中图分类号:

R741

徐娟, 李晔. 铁死亡在阿尔茨海默病中作用的研究进展[J]. 基础医学与临床, 2022, 42(7): 1129-1133.

XU Juan, LI Ye. Research progress on the role of ferroptosis in Alzheimer's disease[J]. Basic & Clinical Medicine, 2022, 42(7): 1129-1133.

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铁死亡在阿尔茨海默病中作用的研究进展

Research progress on the role of ferroptosis in Alzheimer's disease

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