褪黑素在扩张型心肌病中作用的研究进展

doi:10.16352/j.issn.1001-6325.2022.07.1148

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (7): 1148-1151.doi: 10.16352/j.issn.1001-6325.2022.07.1148

褪黑素在扩张型心肌病中作用的研究进展

刘佳¹, 徐锴², 石瑞正¹, 张国刚^2*

1.中南大学湘雅医院心血管内科, 湖南长沙 410008;
2.中南大学湘雅三医院心血管内科, 湖南长沙 410013

收稿日期:2021-02-09 修回日期:2021-06-15 出版日期:2022-07-05 发布日期:2022-06-29
通讯作者: * xyzgg2006@sina.com

Progress on the role of melatonin in dilated cardiomyopathy

LIU Jia¹, XU Kai², SHI Rui-zheng¹, ZHANG Guo-gang^2*

1. Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha 410008;
2. Department of Cardiovascular Medicine, the Third Xiangya Hospital, Central South University, Changsha 410013, China

Received:2021-02-09 Revised:2021-06-15 Online:2022-07-05 Published:2022-06-29
Contact: * xyzgg2006@sina.com

摘要/Abstract

摘要： 扩张型心肌病(简称扩心病,DCM)表现为心肌收缩功能下降伴有左和/或双心室扩大,目前尚无能够有效延缓病情进展的药物。褪黑素(Mel)通过调节细胞损伤、氧化应激等病理过程在多种心血管疾病中介导延缓心肌重构、保护心功能的作用。DCM与Mel密切关联,有研究证实Mel在延缓DCM疾病进展中起到重要作用。

关键词: 褪黑素, 扩张型心肌病, 心血管保护作用

Abstract: Dilated cardiomyopathy (DCM) is characterized by decreased systolic function and left or biventricular enlargement. There is no single specific medicine to delay the progression of DCM. Melatonin (Mel) plays a key role in many cardiovascular diseases by regulating cell damage, oxidative stress and other pathological processes,delaying myocardial remodeling and protecting cardiac function. There is a close relationship between DCM and Mel. It is confirmed that Mel plays an important role in delaying the progression of DCM.

Key words: melatonin, dilated cardiomyopathy, cardioprotective effect

中图分类号:

R542.2

刘佳, 徐锴, 石瑞正, 张国刚. 褪黑素在扩张型心肌病中作用的研究进展[J]. 基础医学与临床, 2022, 42(7): 1148-1151.

LIU Jia, XU Kai, SHI Rui-zheng, ZHANG Guo-gang. Progress on the role of melatonin in dilated cardiomyopathy[J]. Basic & Clinical Medicine, 2022, 42(7): 1148-1151.

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褪黑素在扩张型心肌病中作用的研究进展

Progress on the role of melatonin in dilated cardiomyopathy

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