CBX7蛋白在宫颈癌中的表达及其临床意义

doi:10.16352/j.issn.1001-6325.2022.05.006

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (5): 721-725.doi: 10.16352/j.issn.1001-6325.2022.05.006

CBX7蛋白在宫颈癌中的表达及其临床意义

哈提米汗·买买提, 姑丽克孜·买买提热夏提, 李俞霆, 周常慧, 李榕^*

新疆医科大学公共卫生学院,新疆维吾尔自治区乌鲁木齐 830000

收稿日期:2021-11-12 修回日期:2022-03-24 出版日期:2022-05-05 发布日期:2022-04-28
通讯作者: * lurong_128@126.com
基金资助:
国家自然科学基金(81760468)

Expression of CBX7 protein in cervical cancer and its clinical significance

Hatimihan· MAIMAITI, Gulikezi·MAIMAITIREXIATI, LI Yu-ting, ZHOU Chang-hui, LI Rong^*

School of Public Health,Xinjiang Medical University,Urumqi 830000,China

Received:2021-11-12 Revised:2022-03-24 Online:2022-05-05 Published:2022-04-28
Contact: * lurong_128@126.com

摘要/Abstract

摘要： 目的探讨色素框同源物7(CBX7)蛋白在宫颈癌(CC)组织中的表达及临床意义。方法回顾性收集2013至2020年在新疆医科大学第一附属医院初次诊断为CC并行宫颈切除术的71例CC组织标本。免疫组织化学法检测组织中CBX7的表达。同时收集患者的临床病理资料,跟踪随访后进行生存分析。结果 CBX7在10例CC组织中高表达、19例组织中低表达、42例组织中阴性表达(P＜0.05);CBX7的表达水平在不同临床分期、淋巴转移和脉管侵袭等临床病理特征上均有差异(P＜0.05);与CBX7阴性表达和低表达组患者相比,CBX7高表达CC患者的生存率均明显提高(P＜0.05),不同CBX7表达量的患者生存率间差异显著(P＜0.05);结论 CC组织中CBX7蛋白阴性表达可能与CC患者预后不佳有关。CC组织CBX7表达可能是一个影响CC患者生存的重要预后因素。

关键词: 宫颈癌, CBX7的表达, 预后, 临床意义

Abstract: Objective To investigate the expression and clinical significance of chomobox homolog 7 (CBX7) in cervical cancer(CC)tissues. Methods Tissue samples of 71 patients with CC who were first diagnosed with CC and underwent cervical resection in the First Affiliated Hospital of Xinjiang Medical University from 2013 to 2020 were retrospectively collected. The expression of CBX7 was detected by immunohistochemistry(IHC). At the same time, data of clinical pathology from the patients were collected and survival analysis was conducted after following-up. Results CBX7 was highly expressed in 10 CC tissues, moderately low in 19 CC tissues, and negative in 42 CC tissues(P＜0.05). The expression of CBX7 was different and rlated to clinical stages, lymphatic metastasis and vascular invasion(P＜0.05). Compared with the negative and low CBX7 expression groups, the survival rate of CC patients with high CBX7 expression was significantly enhanced (P＜0.05)and the survival rate of patients with different CBX7 expression levels were significantly different (P＜0.05). Conclusions The negative expression of CBX7 protein in CC tissues may be associated with poor prognosis of CC patients.CBX7 expression in CC tissues is a potential prognostic fact of CC patients.

Key words: cervical cancer, expression of CBX7, prognosis, clinical significance

中图分类号:

哈提米汗·买买提, 姑丽克孜·买买提热夏提, 李俞霆, 周常慧, 李榕. CBX7蛋白在宫颈癌中的表达及其临床意义[J]. 基础医学与临床, 2022, 42(5): 721-725.

Hatimihan· MAIMAITI, Gulikezi·MAIMAITIREXIATI, LI Yu-ting, ZHOU Chang-hui, LI Rong. Expression of CBX7 protein in cervical cancer and its clinical significance[J]. Basic & Clinical Medicine, 2022, 42(5): 721-725.

参考文献

[1] 苏博,闫振宇,郝尚辉,等.宫颈癌患者癌组织中IL-33表达水平与临床病理特征及预后的相关性[J].实用医学杂志,2021,37:2214-2218.
[2] Musa J, Achenbach CJ, O'Dwyer LC, et al. Effect of cervical cancer education and provider recommendation for screening on screening rates: a systematic review and meta-analysis[J].PLoS One,2017,12:e0183924.doi:10.1371/journal.pone.0190661.
[3] Thaker PH, Salani R, Brady WE, et al. A phase I trial of paclitaxel, cisplatin, and veliparib in the treatment of persistent or recurrent carcinoma of the cervix: an NRG oncology study (NCT#01281852)[J].Ann Oncol,2017,28:505-511.
[4] Canfell K, Kim JJ, Brisson M, et al. Mortality impact of achieving WHO cervical cancer elimination targets: a comparative modelling analysis in 78 low-income and lower-middle-income countries[J].Lancet,2020,395:591-603.
[5] 陈茜,刘宪,崔南,等.敲除EZH2抑制人宫颈癌细胞系迁移和侵袭[J].基础医学与临床,2022,42:395-400.
[6] Ni SJ, Zhao LQ, Wang XF, et al. CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-κB-miR-21 pathways[J].J Hematol Oncol,2018,11:17.doi:10.1186/s13045018-0562-z.
[7] Ni SJ, Wang H, Zhu X, et al. CBX7 suppresses cell proliferation, migration, and invasion through the inhibition of PTEN/Akt signaling in pancreatic cancer[J].Oncotarget,2017,8:8010-8021.
[8] To KK,Tong WS,Wu WK,et al.PPAR gamma agonists sensitize PTEN-deficient lung cancer cells resistant to EGFR tyrosine kinase inhibitors[J].Eur J Pharmacol,2018.doi:10.1016/j.ejphar.2018.01.036.
[9] 刘俊雅,范姝婕,黄薇,等.Hsp90在胰腺癌组织中表达升高及其临床病理意义[J].基础医学与临床,2018,38:497-501.
[10] Gong Lf,Tang Y,Jiang L,et al. Regulation of circ GOLPH3 and its binding protein CBX7 on the proliferation and apoptosis of prostate cancer cells[J].Biosci Rep,2020,40.doi:10.1042/BSR20200936.
[11] Huang ZN,Yan YL,Zhu Z,et al. CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10-ERK signaling[J].Cell Death Dis,2021,12:537.doi:10.1038/s41419-021-03819-0.
[12] 彭友多,王宏伟,何嘉琦,等.胰腺癌病人肿瘤组织CBX7的表达与预后的关系[J].外科理论与实践,2017,22:228-232.
[13] Meseure DD,Vacher SP,Alsibai KD,et al.Expression of anril-polycomb complexes-CDKN2A/B/ARF genes in breast tumors: identification of a two-gene (EZH2/CBX7) signature with independent prognostic value[J]. Mol Cancer Res,2016,14:623-633.

[1]	李顺乐, 李蓉, 田亚亚, 冉小丽, 赵延培, 徐蒙. 血清KLF5和actinin-4水平与肝细胞肝癌肝动脉化疗栓塞术治疗预后的关系[J]. 基础医学与临床, 2024, 44(9): 1284-1289.
[2]	侯楠, 刘源, 高俊, 王晶, 袁萌. 全血NPM1、MCP-1和肠道菌群与胃癌进展及预后相关[J]. 基础医学与临床, 2024, 44(8): 1137-1142.
[3]	操辰新, 唐辉, 耿瑞璇, 郭伏平, 白春梅, 王颖轶, 李太生. 循环CD4⁺CD45RA⁺CD62L⁺ T细胞与接受EGFR-TKI治疗的转移性非小细胞肺癌预后相关[J]. 基础医学与临床, 2024, 44(5): 658-664.
[4]	杨铠菲, 朱静格, 张洋洋, 赵俊果, 高雨悦, 胡焕焕, 姬国杰. 索拉菲尼诱导的细胞凋亡和自噬对HeLa细胞耐药性的影响[J]. 基础医学与临床, 2024, 44(4): 467-473.
[5]	丁飞, 王洒, 黄常新. 非小细胞肺癌患者血清CA211水平和NK细胞数与预后相关[J]. 基础医学与临床, 2024, 44(2): 180-184.
[6]	张伟, 张振, 杨连任, 梁伟. 肺癌7项抗体水平与NSCLC患者化疗效果及预后的关系[J]. 基础医学与临床, 2024, 44(10): 1383-1387.
[7]	周昕羽, 汤继宏, 肖潇, 冯隽, 杨乐天, 徐欢, 武银银. 儿童急性B淋巴细胞白血病合并化疗诱导周围神经病变的临床特点及预后分析[J]. 基础医学与临床, 2024, 44(10): 1394-1399.
[8]	依马木买买提江·阿布拉, 帕哈尔丁·白克热, 易超, 佟庆. 血浆hsa_circ_005230在原发性肝细胞癌诊断和预后评估中的临床价值[J]. 基础医学与临床, 2023, 43(9): 1417-1422.
[9]	贡子琦, 吴晓雯, 郭倩, 郭军, 孔燕. PTEN突变对黏膜黑色素瘤患者临床病理特征及预后的影响[J]. 基础医学与临床, 2023, 43(9): 1341-1345.
[10]	张禹鑫, 朱紫薇, 张燕, 胡玉红. 山萘酚调控VPS9D1-AS1/miR-377-3p对人宫颈癌细胞系SiHa增殖和凋亡的影响[J]. 基础医学与临床, 2023, 43(7): 1069-1078.
[11]	张永梅, 张志敏, 周洁, 潘志兰, 冯丽倩, 杨彦. LncRNA CBR3-AS1在多发性骨髓瘤中的表达及临床意义[J]. 基础医学与临床, 2023, 43(6): 948-952.
[12]	薛剑超, 王亚东, 李博文, 刘新宇, 梁乃新, 李单青. DNA甲基化在肺癌发生及预后中作用的研究进展[J]. 基础医学与临床, 2023, 43(3): 514-518.
[13]	谢晓婷, 张雷, 张莉, 董凤, 刘颖, 李光华, 杨兴. ASH2L在幽门螺旋杆菌感染的人胃癌细胞系中的表达及临床意义[J]. 基础医学与临床, 2023, 43(3): 367-373.
[14]	李雨喋, 王宏宇, 韩松, 李俊发. 激活素A通过少突胶质细胞ACVR1C改善缺血性卒中小鼠神经功能的预后[J]. 基础医学与临床, 2023, 43(3): 380-385.
[15]	高朋, 徐丹丹, 张斌, 刘训涛, 舒丽莎. 氯喹对人宫颈癌细胞系HeLa增殖、凋亡及自噬的影响[J]. 基础医学与临床, 2023, 43(10): 1512-1517.

CBX7蛋白在宫颈癌中的表达及其临床意义

Expression of CBX7 protein in cervical cancer and its clinical significance

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价