单核苷酸多态性和免疫细胞在糖尿病肾脏疾病中的研究进展

doi:10.16352/j.issn.1001-6325.2022.02.019

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (2): 335-339.doi: 10.16352/j.issn.1001-6325.2022.02.019

单核苷酸多态性和免疫细胞在糖尿病肾脏疾病中的研究进展

郭梦然^1,2, 闵行^1,2, 叶月^1,2, 许晓双^1,2, 甄东户^2*

1.兰州大学第一临床医学院内分泌科, 甘肃兰州 730030;
2.兰州大学第一医院内分泌科, 甘肃兰州 730030

收稿日期:2020-10-13 修回日期:2021-01-04 发布日期:2022-01-24
通讯作者: ^* zhdh8279@163.com
基金资助:
中央高校基本科研业务费专项资金重点项目(2022142zrk012);标准化代谢性疾病管理中心专项研究基金(2018-mmczxjj-3);甘肃省自然科学基金资助(18JR3RA314)

Research progress of single nucleotide polymorphisms and immune cells in diabetic kidney disease

GUO Meng-ran^1,2, MIN Hang^1,2, YE Yue^1,2, XU Xiao-shuang^1,2, ZHEN Dong-hu^2*

1. Department of Endocrinology, the First College of Clinical Medicine, Lanzhou University, Lanzhou 730030;
2. Department of Endocrinology, the First Hospital of Lanzhou University,Lanzhou 730030, China

Received:2020-10-13 Revised:2021-01-04 Published:2022-01-24
Contact: ^* zhdh8279@163.com

摘要/Abstract

摘要： 糖尿病肾脏疾病具有很明显的家族聚集性及种族差异,已经确定了一些与糖尿病肾脏疾病易感性有关的单核苷酸多态性(SNPs),尤其是吞噬和细胞运动性1基因(ELMO1)和氯化钠共转运蛋白基因(SLC12A3),与中国人群糖尿病肾脏疾病发展进展有关;同时炎性反应在糖尿病肾脏疾病的发生和发展中起着关键作用,其中细胞和2型固有淋巴细胞(ILC2)分泌炎性因子促进肾脏慢性炎性反应及纤维化。

关键词: 糖尿病肾脏疾病, 单核苷酸多态性, 慢性炎性反应

Abstract: Diabetic kidney disease has obvious family aggregation and ethnic differences, some single nucleotide polymorphisms (SNPs) related to the susceptibility of diabetic kidney disease have been identified, especially engulfment and cell motility 1 (ELMO1) and solute carrier family 12 member 3(SLC12A3), which are related to the development of diabetic kidney disease in Chinese population. Meanwhile, inflammation plays a key role in the occurrence and development of diabetic kidney disease, including T cell and type-2 innate lymphoid cell(ILC2) promote chronic inflammatory response and fibrosis of kidney by secreting inflammatory factors.

Key words: diabetic kidney disease, the single nucleotide polymorphisms, chronic inflammatory reaction

中图分类号:

郭梦然, 闵行, 叶月, 许晓双, 甄东户. 单核苷酸多态性和免疫细胞在糖尿病肾脏疾病中的研究进展[J]. 基础医学与临床, 2022, 42(2): 335-339.

GUO Meng-ran, MIN Hang, YE Yue, XU Xiao-shuang, ZHEN Dong-hu. Research progress of single nucleotide polymorphisms and immune cells in diabetic kidney disease[J]. Basic & Clinical Medicine, 2022, 42(2): 335-339.

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单核苷酸多态性和免疫细胞在糖尿病肾脏疾病中的研究进展

Research progress of single nucleotide polymorphisms and immune cells in diabetic kidney disease

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