10 661例体检者幽门螺杆菌感染情况及其相关危险因素分析

doi:10.16352/j.issn.1001-6325.2022.01.019

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (1): 126-130.doi: 10.16352/j.issn.1001-6325.2022.01.019

10 661例体检者幽门螺杆菌感染情况及其相关危险因素分析

雷蓉, 杨丹, 袁芳桃, 周小燕, 江毅敏, 柳弥^*

川北医学院附属医院健康管理中心健康管理研究室, 四川南充 637000

收稿日期:2021-03-08 修回日期:2021-06-03 出版日期:2022-01-05 发布日期:2022-01-05
通讯作者: ^* liumi69599@163.com
基金资助:
川北医学院附属医院科研发展项目(2019JC035)

An investigation of Helicobacter pylori infection and potential risk factors of colonization found in 10 661 cases from routine physical examination

LEI Rong, YANG Dan, YUAN Fang-tao, ZHOU Xiao-yan, JIANG Yi-min, LIU Mi^*

Health Management Center, Health Management Laboratory, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

Received:2021-03-08 Revised:2021-06-03 Online:2022-01-05 Published:2022-01-05
Contact: ^* liumi69599@163.com

摘要/Abstract

摘要： 目的了解健康体检人群幽门螺杆菌感染情况及相关危险因素分析。方法对2019年1月1日至2020年12月30日在川北医学院附属医院行碳13/尿素呼气试验(¹³C-UBT)的10 661例健康体检人群作为研究对象进行回顾性分析。根据幽门螺杆菌(H.pylori)感染情况将受检者分为H.pylori阳性组和H.pylori阴性组,分析H.pylori感染与血小板(PLT)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FBG)、T3、T4、TSH、胃蛋白酶原Ⅰ(pepsinogenⅠ)、胃蛋白酶原Ⅱ(pepsinogenⅡ)、胃泌素17(G-17)、同型半胱氨酸(Hcy)、尿酸(UA)、总胆红素(TBIL)之间的关系。结果 1)阳性感染总人数:4 382例,总阳性率:41.10%,其中男性阳性感染人数2 717例,阳性率25.49%;女性阳性感染人数1 665例,阳性率15.62%,男性高于女性(P＜0.05);2)H.pylori阳性组和阴性组相比:阳性组年龄稍低于阴性组(P＜0.05),HDL-C、pepsinogenⅠ/Ⅱ、Hcy和TBIL均低于阴性组(P＜0.05)。H.pylori阳性组在BMI、收缩压、舒张压、TG、FBG、pepsinogenⅠ、pepsinogenⅡ和G-17均高于阴性组(P＜0.05)。3)DOB值高低与年龄、FBG、pepsinogenⅠ、pepsinogenⅡ、G-17和pepsinogenⅠ/Ⅱ和TBIL相关(P＜0.001)。4)进一步将P＜0.05的参数纳入二元Lojistic回归分析,男性、BMI、FBG、pepsinogenⅡ、pepsinogenⅠ/Ⅱ为幽门螺杆菌感染的危险因素(P＜0.05)。结论 H.pylori感染在男性人群中更为常见,BMI、FBG、pepsinogenⅡ、pepsinogenⅠ/Ⅱ为H.pylori感染的危险因素。早期干预这些危险因素有望减少H.pylori的感染,为胃肠道疾病的一级预防提供理论依据。

关键词: 幽门螺旋杆菌, 碳13/尿素呼气试验(¹³C-UBT), 危险因素, 相关性

Abstract: Objective To investigate the situation of Helicobacter pylori(H.pylori) infection in healthy people and analyze the related risk factors. Methods Retrospective analysis was conducted on 10 661 healthy subjects who underwent carbon 13-urea breath test (¹³C-UBT)on January 1, 2019 to December 30, 2020 in affiliated hospital of North Sichuan Medical College. According to the infection status of Helicobacter pylori (H.pylori), the subjects were divided into H.pylori positive group and H.pylori negative group. H.pylori infection and platelet (PLT), triglyceride(TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), T3, T4, TSH and pepsinogen Ⅰ (pepsinogen Ⅰ) were analyzed. PepsinogenⅠ, pepsinogen Ⅱ(pepsinogen), gastrin 17(G-17), homocysteine (Hcy), uric acid (UA) and total bilirubin (TBIL)were also examined. Results 1)The total number of positive infections: 4 382, the total positive rate: 41.10%, including 2 717 male positive cases with morbidity as 25.49%. There were 1 665 cases of positive infection in females, and the morbidity was 15.62%, which was lower than that in males (P＜0.05). 2)Compared with the negative group, the age of the positive group was slightly lower than that of the negative group (P＜0.05), and the HDL-C, pepsinogen Ⅰ/Ⅱ, Hcy and TBil were all lower than those of the negative group (P＜0.05). BMI, SBP, DBP, TG, FBG, pepsinogen Ⅰ, pepsinogen and G-17 in H.pylori positive group were all higher than those in negative group (P＜0.05). 3)DOB value was correlated with age, FBG, pepsinogen Ⅰ, pepsinogen, G-17, pepsinogen Ano/Cha and TBil (P＜0.001). 4) The parameters P＜0.05 were further included in binary Logistic regression analysis, and male, BMI, FBG, pepsinogen Ⅱ, pepsinogen branch/root were risk factors for H.pylori infection (P＜0.05). Conclusions H.pylori infection is more common in male population, BMI, FBG, pepsinogen Ⅱ, pepsinogen L/N are the risk factors for H.pylori infection. Early intervention of these risk factors is expected to reduce the infection of H.pylori and provide theoretical basis for the primary prevention of this gastrointestinal diseases.

Key words: Helicobacter pylori, carbon13-urea breath test (¹³C-UBT), risk factors, correlation

中图分类号:

R543.5

雷蓉, 杨丹, 袁芳桃, 周小燕, 江毅敏, 柳弥. 10 661例体检者幽门螺杆菌感染情况及其相关危险因素分析[J]. 基础医学与临床, 2022, 42(1): 126-130.

LEI Rong, YANG Dan, YUAN Fang-tao, ZHOU Xiao-yan, JIANG Yi-min, LIU Mi. An investigation of Helicobacter pylori infection and potential risk factors of colonization found in 10 661 cases from routine physical examination[J]. Basic & Clinical Medicine, 2022, 42(1): 126-130.

参考文献

[1]Mitchell H, Katelaris P. Epidemiology, clinicalimpacts and current clinical management of Helicobacter pylori infection[J].Med J Aust, 2016,204:376-380.
[2]Park JY, Forman D, Waskito LA, et al.Epidemiology of Helicobacter pylori and CagA-positive infections and global variations in gastric cancer[J]. Toxins,2018,10:163-166.
[3]幽门螺杆菌-尿素呼气试验临床应用专家共识(2020年)[J].中华消化杂志,2020,40:797-802.
[4]Santos MLC, de Brito BB, da Silva FAF,et al.Helicobacter pylori infection: beyond gastric manifestations[J].World J Gastroenterol. 2020 Jul 28; 26: 4076-4093.
[5]Wan Z,Hu L,Hu M,et al. Helicobacter pylori infection and prevalence of high blood pressure among Chinese adults[J]. J Hum Hypertens,2018,32:158-164.
[6]魏文志,刘艳如,温晓华,等.健康体检人群幽门螺杆菌感染与高同型半胱氨酸血症的关系[J].中华保健医学杂志,2018,20:7-9.
[7]贺姣,薛兵,周玉霞,等.幽门螺杆菌感染对帕金森病合并糖尿病视网膜病变患者糖代谢和氧化应激及视网膜病变的影响[J].中华医院感染学杂志,2020,30:409-413.
[8]刘青,黄婷婷,曹朝鹏,等.体检人群幽门螺杆菌感染者血清葡萄糖、脂类及同型半胱氨酸水平与Hp抗体分型的相关分析[J].现代检验医学杂志,2019,34:49-52+57.
[9]Shi Y, Duan JY, Liu DW,et al.Helicobacter pylori infection is associated with occurrence of proteinuria in type 2 diabetes patients: a systemic review and Meta-analysis[J].Chin Med J (Engl), 2018,131:2734-2740.
[10]贺姣,薛兵,周玉霞,等.幽门螺杆菌感染对帕金森病合并糖尿病视网膜病变患者糖代谢和氧化应激及视网膜病变的影响[J].中华医院感染学杂志,2020,30:409-413.
[11]den Hollander WJ,Holster IL,den Hoed CM,et al.Surveillance of premalignant gastric Ⅰ esions: a multicentre prospective cohort study from low incidence regions[J].Gut,2019;68:585-593.
[12]刘东涛,李兵,孙坤.血清PGⅠ、GS-17及TNF-α水平与幽门螺杆菌感染消化性溃疡相关性研究[J].临床误诊误治,2021,34:58-63.
[13]庄伟,计钰亮,朱婷婷. 早期胃癌胃镜筛查中联合应用血清PG、G-17、CA72-4及Hp检测的价值研究[J]. 浙江医学,2020,42:1529-1532.
[14]Eisdorfer I,Shalev V,Goren S,et al.Sex differences in urea breath test results for the diagnosis of Helicobacter pylori infection: a large cross-sectional study[J].Biol Sex Differ,2018,9: 1.doi:10.1186/s13293-017-0161-7.
[15]刘卫东,惠文佳,孔文洁,等.不同类型幽门螺杆菌感染与血清胃蛋白酶原水平的相关性[J].基础医学与临床,2019,39:400-401.

10 661例体检者幽门螺杆菌感染情况及其相关危险因素分析

An investigation of Helicobacter pylori infection and potential risk factors of colonization found in 10 661 cases from routine physical examination

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	付志刚, 覃佳, 谭江山. 门脉高压性肺动脉高压:诊治进展与挑战[J]. 基础医学与临床, 2024, 44(8): 1068-1073.
[2]	张佳, 王艳丽, 宋晓丛, 王淑珍. 张家口市高血压视网膜病变患者情况调查及危险因素分析[J]. 基础医学与临床, 2024, 44(6): 853-857.
[3]	张玉苓, 张珂, 许艇, 张庆. 胎儿生长受限孕妇胎盘自噬相关蛋白表达水平及其临床意义[J]. 基础医学与临床, 2024, 44(4): 528-532.
[4]	徐璐, 张冬雨, 王瑞锋. 茯苓酸调节PI3K/AKT/NF-κB信号通路对大鼠幽门螺旋杆菌相关性胃炎的治疗作用[J]. 基础医学与临床, 2024, 44(4): 489-495.
[5]	魏丹丹, 宋宇涵, 王淇, 宿树兰, 朱悦, 段金廒. 年龄相关性黄斑变性的研究进展[J]. 基础医学与临床, 2024, 44(4): 553-557.
[6]	韩惠晶, 吴红, 葛银, 乔娟. 右美托咪定减轻呼吸机相关性肺损伤模型大鼠肺组织损伤[J]. 基础医学与临床, 2024, 44(3): 339-345.
[7]	周昕羽, 汤继宏, 肖潇, 冯隽, 杨乐天, 徐欢, 武银银. 儿童急性B淋巴细胞白血病合并化疗诱导周围神经病变的临床特点及预后分析[J]. 基础医学与临床, 2024, 44(10): 1394-1399.
[8]	王春源, 边立立, 李肖肖. 北京月坛社区老年高血压患者抑郁情绪调查及危险因素分析[J]. 基础医学与临床, 2023, 43(5): 798-803.
[9]	张乐, 苑雨辰, 张越伦, 申乐. 胸腔镜手术慢性术后疼痛风险预测模型的构建[J]. 基础医学与临床, 2023, 43(4): 651-655.
[10]	谢晓婷, 张雷, 张莉, 董凤, 刘颖, 李光华, 杨兴. ASH2L在幽门螺旋杆菌感染的人胃癌细胞系中的表达及临床意义[J]. 基础医学与临床, 2023, 43(3): 367-373.
[11]	张雨, 韩悦, 朱倩梅, 周会影, 苗煦涵, 姚晶曼, 刘子嘉, 申乐. 老年患者电视胸腔镜手术后肺部并发症的危险因素分析[J]. 基础医学与临床, 2023, 43(12): 1847-1851.
[12]	李雨婷, 范永君, 孟琰, 隋芳, 韩常新. 辽南地区2020年度COVID-19流行病学及临床特征分析[J]. 基础医学与临床, 2022, 42(10): 1577-1580.
[13]	乔逸, 肖河, 樊晓红, 石冰冰, 纪志刚. 肾结石患者低柠檬酸尿症代谢相关危险因素分析[J]. 基础医学与临床, 2021, 41(8): 1177-1180.
[14]	孔德欣, 黄薇, 杨楠, 刘雁勇. 多肽P7对肿瘤组织的靶向识别与Hsp90表达水平相关[J]. 基础医学与临床, 2021, 41(7): 982-987.
[15]	范俊平, 周婧雅, 秦岭, 张晟瑜, 叶葳, 潘慧, 李航. 内科住院医师客观结构化临床考试成绩和培训表现相关性[J]. 基础医学与临床, 2020, 40(10): 1449-1452.