人端粒酶反转录酶线粒体转位的研究进展

摘要/Abstract

摘要： 端粒酶反转录酶是端粒酶的亚单位,在维持端粒酶活性和调节细胞周期的过程中起关键作用。人端粒酶反转录酶(hTERT)主要在生殖细胞、胚胎干细胞和肿瘤细胞中高表达,参与肿瘤发生、发展,在正常细胞中亦有少量表达;hTERT主要位于细胞核内,线粒体中也有分布。hTERT从细胞核内穿过核孔移入线粒体,使得线粒体内hTERT增加,称为hTERT的线粒体转位。hTERT线粒体转位在细胞凋亡、细胞永生化和细胞耐药中均发挥作用。对hTERT的调控可能成为某些疾病治疗的新突破。

关键词: 人端粒酶反转录酶, 线粒体转位, 细胞凋亡

Abstract: Telomerase reverse transcriptase is a subunit of telomerase, which plays an important role in activating telomerase and regulating cell cycle. Human telomerase reverse transcriptase(hTERT) is mainly expressed in germ cells, embryonic stem cells and tumor cells, only a few expressed in normal cell. hTERT is mainly located in nucleus and also distributed in mitochondria. hTERT migration from nucleus into mitochondria is called the mitochondrial translocation of hTERT. Mitochondrial translocation of hTERT functions in the process of apoptosis, immortalization and drug resistance. Control of hTERT is a potential breakthrough in the treatment of diseases.

Key words: human telomerase reverse transciptase, mitochondrial translocation, cell apoptosis

中图分类号:

胡惟恺, 刘瑞霞, 阴赪宏. 人端粒酶反转录酶线粒体转位的研究进展[J]. 基础医学与临床, 2021, 41(12): 1818-1822.

HU Wei-kai, LIU Rui-xia, YIN Cheng-hong. Research progress on mitochondrial translocation of human telomerase reverse transcriptase[J]. Basic & Clinical Medicine, 2021, 41(12): 1818-1822.

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