性别、年龄和季节对血清25-羟维生素D水平的影响

基础医学与临床 ›› 2020, Vol. 40 ›› Issue (2): 151-154.

性别、年龄和季节对血清25-羟维生素D水平的影响

王丹晨, 尹逸丛, 禹松林, 张瑞丽, 高学慧, 李洪雷, 程歆琦, 邱玲^*

中国医学科学院北京协和医学院北京协和医院检验科, 北京 100730

收稿日期:2019-02-20 修回日期:2019-05-04 出版日期:2020-02-05 发布日期:2020-02-05
通讯作者: ^*lingqiubj@aliyun.com
基金资助:
国家自然科学基金青年项目(81702060); 宁夏重点研发计划-重大重点项目(东西部合作项目)(2018BFG02010)

Effect of gender, age and season on serum 25-hydroxyvitamin D level

WANG Dan-chen, YIN Yi-cong, YU Song-lin, ZHANG Rui-li, GAO Xue-hui, LI Hong-lei, CHENG Xin-qi, QIU Ling^*

Department of Laboratory Medicine, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730, China

Received:2019-02-20 Revised:2019-05-04 Online:2020-02-05 Published:2020-02-05
Contact: ^*lingqiubj@aliyun.com

摘要/Abstract

摘要： 目的探讨性别、年龄和季节对血清25-羟维生素D(25OHD)的影响。方法调取2014年12月至2018年10月北京协和医院血清25OHD检测结果,共计34 062例。采用罗氏e601自动分析仪及其配套试剂检测血清25OHD。应用回归分析评估性别、年龄和季节对血清25OHD水平的影响。结果男性血清25OHD水平明显高于女性(P＜0.001)。血清25OHD在8月份达到高峰为22.1 ng/mL。夏季对25OHD水平影响最大(标准化系数=0.273)。结论性别和季节显著影响血清25OHD水平。

关键词: 25-羟维生素D, 季节, 性别, 年龄

Abstract: Objective To explore the effect of gender, age and season on serum 25-hydroxyvitamin D(25OHD). Methods Clinical data was collected from the laboratory information system at the Peking Union Medical College Hospital from December 2014 to October 2018. A total of 34 062 25OHD samples were obtained and analyzed. 25OHD concentrations were measured using a Roche e601 automatic analyzer. Regression analysis was used to explore the effect of gender, age and season on 25OHD level. Results The median serum 25OHD concentration was significantly higher in males than that in females(P＜0.001). The median serum 25OHD concentration at the peak level in August was 22.1 ng/mL. Regression analysis revealed that summer had the highest impact on 25OHD (standardization coefficient=0.273). Conclusions Gender and season significantly affected serum 25OHD levels.

Key words: 25-hydroxyvitamin D, season, gender, age

中图分类号:

R446.1

王丹晨, 尹逸丛, 禹松林, 张瑞丽, 高学慧, 李洪雷, 程歆琦, 邱玲. 性别、年龄和季节对血清25-羟维生素D水平的影响[J]. 基础医学与临床, 2020, 40(2): 151-154.

WANG Dan-chen, YIN Yi-cong, YU Song-lin, ZHANG Rui-li, GAO Xue-hui, LI Hong-lei, CHENG Xin-qi, QIU Ling. Effect of gender, age and season on serum 25-hydroxyvitamin D level[J]. Basic & Clinical Medicine, 2020, 40(2): 151-154.

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