长链非编码RNAs调控骨稳态研究进展

基础医学与临床 ›› 2020, Vol. 40 ›› Issue (1): 115-119.

长链非编码RNAs调控骨稳态研究进展

范琳媛¹, 李红凌^2*

1.首都医科大学附属北京妇产医院妇科, 北京 100026;
2.中国医学科学院基础医学研究所北京协和医学院基础学院组织工程中心, 北京 100005

收稿日期:2019-05-01 修回日期:2019-11-04 出版日期:2020-01-05 发布日期:2019-12-27
通讯作者: ^*lihongling2007@163.com

Research progress in the regulation of bone homeostasis by long noncoding RNAs

FAN Lin-yuan¹, LI Hong-ling^2*

1. Department of Gynecology,Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026;
2. Center of Excellence in Tissue Engineering, Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC, Beijing 100005, China

Received:2019-05-01 Revised:2019-11-04 Online:2020-01-05 Published:2019-12-27
Contact: ^*lihongling2007@163.com

摘要/Abstract

摘要： 骨形成和骨吸收是骨稳态维持的两个重要过程,骨稳态失衡可导致多种骨代谢疾病的发生。长链非编码RNAs(lncRNAs)是一类几乎不具有编码功能的RNAs,在调节基因表达、生命发育及疾病发生发展中起重要调控作用。在骨代谢疾病中多种lncRNAs表达异常,lncRNAs 通过调节成软骨分化、成骨分化和骨基质矿化过程,调控骨的形成。并通过影响破骨细胞的分化和成熟,参与骨吸收过程的调节。

关键词: 长链非编码RNAs, 骨稳态, 骨形成, 骨吸收

Abstract: Bone formation and bone resorption are two important processes of bone homeostasis maintenance, and the imbalance of bone homeostasis can lead to a variety of bone metabolic diseases. Long noncoding RNAs (lncRNAs) are a subset of RNAs with only rarely encoding proteins and play important regulatory role in regulation of gene expression, life development and disease occurrence.In bone metabolic diseases, lots of lncRNAs are abnormally expressed. LncRNAs regulate bone formation process through regulating chondrogenic differentiation, osteogenic differentiation and bonematrix mineralization. By affecting the differentiation and maturation of osteoclasts,lncRNAs are involved in the regulation of bone resorption.

Key words: long noncoding RNAs, bone homeostasis, bone formation, bone resorption

中图分类号:

R681

范琳媛, 李红凌. 长链非编码RNAs调控骨稳态研究进展[J]. 基础医学与临床, 2020, 40(1): 115-119.

FAN Lin-yuan, LI Hong-ling. Research progress in the regulation of bone homeostasis by long noncoding RNAs[J]. Basic & Clinical Medicine, 2020, 40(1): 115-119.

参考文献

[1]Laurent GS,Wahlestedt C,Kapranov P. The Landscape of long noncoding RNA classification[J]. Trends Genet, 2015, 31: 239-251.
[2]Perry RB, Ulitsky I. The functions of long noncoding RNAs in development and stem cells[J]. Development, 2016,143: 3882-3894.
[3]Faulkner B, Astleford K, Mansky KC. Regulation of osteoclast differentiation and skeletal maintenance by histone deacetylases[J]. Molecules, 2019, 24:1355-1372.
[4]Majidinia M, Sadeghpour A, Yousefi B, The roles of signaling pathways in bone repair and regeneration [J]. J Cell Physiol,2018, 233: 2937-2948.
[5]Li J, Wang Q, Yang R, et al. BMI-1 mediates estrogen deficiency induced bone loss by inhibiting reactive oxygen species accumulation and T cell activation[J]. J Bone Miner Res, 2017, 32: 962-973.
[6]Allas L, Boumédiene K, Baugé C. Epigenetic dynamic during endochondral ossification and articular cartilage development[J]. Bone, 2019, 120:523-532.
[7]Liang W, Fu W, Wang Y, et al. H19 activates Wnt signaling and promotes osteoblast differentiation by function-ing as a competing endogenous RNA[J]. Sci Rep, 2016, 6: 20121-20131.
[8]Liao JY, Yu XY, Hu X, et al. lncRNA H19 mediates BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs) through Notch signaling[J]. Oncotarget, 2017,8: 53581-53601.
[9]Huang Y, Zheng Y, Jia L, et al. Long noncoding RNA H19 promotes osteoblast differentiation Via TGF-beta1/Smad3/HDAC signaling pathway by deriving miR-675[J]. Stem Cells, 2015, 33:3481-3492.
[10]Wu J, Zhao J, Sun L, et al. Zhang, Long non-coding RNA H19 mediates mechanical tension-induced osteo-genesis of bone marrow mesenchymal stem cells via FAK by sponging miR-138[J]. Bone, 2018,108: 62-70.
[11]Simion V, Haemmig S, Feinberg MW. LncRNAs in vascular biology and disease[J]. Vasc Pharmacol, 2018, 114:145-156.
[12]Xiao X, Zhou T, Guo S, et al. LncRNA MALAT1 sponges miR-204 to promote osteoblast differentiation of human aortic valve interstitial cells through up-regulating Smad4[J]. Int J Cardiol, 2017, 243: 404-412.
[13]Gao Y, Xiao F, Wang C,et al.Long noncoding RNA MALAT1 promotes osterix expression to regulate osteo-genic differentiation by targeting miRNA-143 in human bone marrow-derived mesenchymal stem cells[J].J Cell Biochem, 2018,119:6986-6996.
[14]Zhang L, Chen S, Bao N, et al. Sox4 enhances chondrogenic differentiation and proliferation of human synovium-derived stem cell via activation of long noncoding RNA DANCR[J]. J Mol Histol, 2015,46: 467-473.
[15]Zhang L, Yang C, Chen S, et al. Long noncoding RNA DANCR is a positive regulator of proliferation and chondrogenic differentiation in human synovium-derived stem cells[J]. DNA Cell Biol, 2017, 36: 136-142
[16]Zhuang W, Ge X, Yang S, et al. Upregulation of lncRNA MEG3 promotes osteogenic differentiation of mesenchymal stem cells from multiple myeloma patients by targeting BMP4 transcription[J]. Stem cells, 2015, 33: 1985-1997.
[17]Li Z, Jin C, Chen S, et al. Zhou, Long non-coding RNA MEG3 inhibits adipogenesis and promotes osteogenesis of human adipose-derived mesenchymal stem cells via miR-140-5p[J]. Mol Cell Biochem, 2017,433: 51-60.
[18]Wang Q, Li Y, ZhangY,et al. LncRNA MEG3 inhibited osteogenic differentiation of bone marrow mesenchymal stem cells from postmenopausal osteoporosis by targeting miR-133a-3p[J]. Biomed Pharmacother, 2017,89: 1178-1186.
[19]Jin C, Zheng Y, Huang Y, et al. Long non-coding RNA MIAT knockdown promotes osteogenic differentiation of human adipose-derived stem cells[J].Cell Biol Int, 2017,41: 33-41.
[20]Fang B, Li Y, Chen C,et al. Huo Xue Tong Luo capsule ameliorates osteonecrosis of femoral head through inhibit-ing lncRNA-Miat[J]. J Ethnopharmacol, 2019,238:111862-111868.
[21]Shih JW, Chiang WF, Wu ATH, et al. Long noncoding RNA Lnc HIFCAR/MIR31HG is a HIF-1alpha co-activator driving oral cancer progression[J]. Nat Commun, 2017, 8: 15874-15889
[22]Jin C, Jia L, Huang Y, et al. Inhibition of lncRNA MIR31HG promotes osteogenic differentiation of human adipose-derived stem cells[J]. Stem cells, 2016, 34: 2707-2720
[23]Dou C, Cao Z, Yang B, et al, Changing expression profiles of lncRNAs, mRNAs, circRNAs and miRNAs during osteoclastogenesis[J]. Sci Rep, 2016, 6:21499-21511.
[24]Lee C, Huang YN, Nithiyanantham S, et al.LncRNA-Jak3:Jak3 coexpressed pattern regulates monosodium urate crystal-induced osteoclast differentiation through Nfatc1/Ctsk expression[J]. Environ Toxicol, 2019, 34: 179-187.
[25]Liu C, Cao Z, Bai Y, et al. LncRNA AK077216 promotes RANKL-induced osteoclastogenesis and bone resorption via NFATc1 by inhibition of NIP45[J].J Cell Physiol, 2019 234:1606-1617.