缩宫素在Prader-Willi综合征中应用的研究进展

基础医学与临床 ›› 2018, Vol. 38 ›› Issue (8): 1178-1182.

缩宫素在Prader-Willi综合征中应用的研究进展

张梦奇,马明圣

北京协和医院

收稿日期:2018-03-01 修回日期:2018-05-24 出版日期:2018-08-05 发布日期:2018-07-24
通讯作者: 马明圣 E-mail:mamingsheng@pumch.cn

Research advance of oxytocin in Prader-Willi syndrome

Meng-Qi zhang¹,

Received:2018-03-01 Revised:2018-05-24 Online:2018-08-05 Published:2018-07-24

摘要/Abstract

摘要： 缩宫素（OXT）是一种神经肽，在情绪控制、食欲和社交等方面发挥重要作用。缩宫素缺乏与Prader-Willi综合征（PWS）中吮吸困难、食欲亢进、社交困难等多种症状相关。短期鼻腔内滴入OXT可明显缓解PWS患儿新生儿期严重的吮吸困难，此外，也可改善年幼患儿社交困难，但对于年长PWS患儿无效并出现脾气暴躁的不良反应。

关键词: Prader-willi综合征, 缩宫素, 肌张力低下

Abstract: Oxytocin (OXT) is a neuropeptide that plays an important role in modulating emotion, appetite, social interactions, and the lack of OXT is related with poor suck, hyperphagia, behavior and social disturbances in patients with Prader-Willi syndrome(PWS). Short course of intranasal OXT administration rescues oral feeding and social skills in infants with PWS, but OXT is no use and could increase temper outburst in older PWS patients. The mechanism of OXT used in PWS patients remains to be further explored since no definitive conclusions have been reached so far. The latest progress of research is discussed in this article.

Key words: Prader-Willi syndrome, oxytocin, hyptonia

中图分类号:

R720.5

张梦奇马明圣. 缩宫素在Prader-Willi综合征中应用的研究进展[J]. 基础医学与临床, 2018, 38(8): 1178-1182.

Meng-Qi zhang. Research advance of oxytocin in Prader-Willi syndrome[J]. Basic & Clinical Medicine, 2018, 38(8): 1178-1182.