基础医学与临床 ›› 2014, Vol. 34 ›› Issue (3): 414-417.
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叶周恒1,刘文武1,孙学军2
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摘要： 程序性坏死是一种具有可调控的信号转导通路的细胞坏死方式。多种刺激可导致程序性坏死的发生，复合体I、复合体II和RIP1-RIP3坏死体是通路中的信号分子，而Necstatin-1是程序性坏死的特异性阻断剂。程序性坏死可能是缺血再灌注损伤中细胞死亡的重要方式。
关键词: 程序性坏死, 受体相互作用蛋白激酶1, 受体相互作用蛋白激酶3
Abstract: Necroptosis is a special cell necrosis that is capable of being regulated through particular molecular mechanism. Multiple stimuli could induce necroptosis , complex I, complex II and RIP1-RIP3 necrosome are critical participants in the necroptosis. Also, necrostatin-1 is a special and potent small-molecular inhibitor of necroptosis. Necroptosis could be an important alternative for cell death in ischemia-reperfusion injury.
Key words: Necroptosis, receptor interaction protein kinase 1, receptor interaction protein kinase 3
中图分类号:
R34
叶周恒 刘文武 孙学军. 程序性坏死机制与缺血再灌注损伤[J]. 基础医学与临床, 2014, 34(3): 414-417.
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