TRPM家族对细胞钙/镁平衡调控的研究进展

基础医学与临床 ›› 2013, Vol. 33 ›› Issue (3): 370-373.

TRPM家族对细胞钙/镁平衡调控的研究进展

张厉¹,杨春喜²,贺石生³

1. 上海市第十人民医院同济大学附属第十人民医院；南京医科大学
2. 上海市第十人民医院同济大学附属第十人民医院
3. 南京医科大学第一临床医学院

收稿日期:2012-04-09 修回日期:2012-07-02 出版日期:2013-03-05 发布日期:2013-03-05
通讯作者: 杨春喜 E-mail:chunxi_yang@163.com
基金资助:
镁离子对成人骨髓间充质干细胞外基质矿化的作用及机制

Recent advances in the regulation effect of TRPM family in cellular calcium / magnesium homeostasis

1. Shanghai tenth People’s Hospital, Tongji University School of Medicine;Nanjing Medical University
2.

Received:2012-04-09 Revised:2012-07-02 Online:2013-03-05 Published:2013-03-05

摘要/Abstract

摘要： TRPM通道是TRP通道超家族的一员。包括TRPM1至TRPM8八个成员，除TRPM4与TRPM5外，其余成员对Ca2+和Mg2+均具有一定通透性。其中TRPM1、TRPM2、TRPM3和TRPM8主要参与调控细胞Ca2+的平衡，而TRPM6和TRPM7是调控细胞Mg2+平衡的关键通道。TRPM家族成员分布广泛，调节机制各异，对于细胞钙/镁平衡等一系列生理功能具有重要调控作用。

关键词: TRPM阳离子通道, 钙离子平衡, 镁离子平衡

Abstract: Melastatin-related transient receptor potential (TRPM) channels belong to the transient receptor potential（TRP）channel superfamily. All the members are permeable to Ca2+ and Mg2+ except TRPM4 and TRPM5. TRPM1, TRPM2, TRPM3 and TRPM8 are regulators of Ca2+ and magnesium homeostasis, TRPM6 and TRPM7 are key regulators of Mg2+ homeostasis. TRPM channels are distributed widely and activated by multiple stimuli. They play fundmental role in regulating cellular calcium / magnesium homeostasis and other various cell biological processes.

Key words: TRPM cation channels, Calcium homeostasis, Magnesium homeostasis

张厉杨春喜贺石生. TRPM家族对细胞钙/镁平衡调控的研究进展[J]. 基础医学与临床, 2013, 33(3): 370-373.