关键词: 系统性红斑狼疮, 抗磷脂抗体, 抗磷脂抗体相关性肾病

Abstract: Abstract：Objective To investigate the renal histopathologic characteristics of antiphoslipid antibody-associated nephropathy(APLN) in patients with Systemic Lupus Erythematosus(SLE) . Methods Data of 155 cases of SLE admitted to Peking Union Medical College Hospital from 2000 to 2005 was reviewed. Kidney biopsy was performed on all of these patients. Using retrospective analysis, we investigated the APLN and APLN-like renal histopathologic characteristics and its correlation with antiphsolipid antibody(APL). Two groups including APL positive group(37 cases, 23.9％) and APL negative group(118 cases, 76.1％) were compared. Results APLN and APLN-Like renal histopathologic lesions were found in 55/155(35.5%) cases of patients with SLE. 46 cases of included fibrous intimal hyperplasia (29.7％), 12 cases of fibrous and/or fibrocelluar occlusions of arteries and arterioles（7.7％）, 3 cases of focal cortical atrophy（1.9%）and 8 cases of tubular thyroidization（5.2％） were showed in all 46/155(29.7%) cases of chronic APLN and APLN-like lesion. Acute APLN and APLN-like lesions(thrombotic microangiopathy) were detected in 14 cases(9.0%). APLN and APLN-like renal histopathologic lesions of were found in 23/37(62.1%) cases in APL positive group and 32/118(27.1%) cases in APL negative group. The incidence of total renal histopathologic lesions (62.1% vs 27.1%) and its chronic and acute lesions in APL positive group were all significantly higher than in APL negative group by logistic regression（P value were all <0.05）. Conclusions High incidence of renal histopathologic lesions of APLN was found in SLE patients. The lesions were high correlated with APL.

Key words: Systemic Lupus Erythematosus, Antiphospholipid antibody, antiphoslipid antibody-associated nephropathy