OBJECTIVE To prepare the paclitaxel liposomes modified with mPEG-DSPE and study its pharmacokinetics in rats.METHODS The mPEG2000-DSPE was synthesized and used to modify the lipid membrane.The paclitaxel liposomes were prepared by a thin-film dispersion method.The concentration of the paclitaxel in rat plasma was determined by HPLC method.RESULTS The particle size of the resulting paclitaxel liposomes was(411.8±31.9)nm,and its encapsulation was(82.47±2.15)%.Pharmacokinetic study showed that t1/2β of paclitaxel injection and paclitaxel liposomes were 1.48 and 10.48 h,respectively.The AUC value of the liposomes was increased.The AUC of liposomes was 3.13 times as that obtained after i.v.administration of the paclitaxel injection.CONCLUSION The in vivo circulating time of the paclitaxel liposomes modified with the mPEG-DSPE could be lengthened,and the AUC has been improved in some extent.
ZHNG Zi-qing;QIN in;LI Zhn;YO Jing.
Preparation of Paclitaxel Liposomes Modified with mPEG-DSPE and Its Pharmacokinetics in Rats [J]. Chinese Pharmaceutical Journal, 2008, 43(03): 199-202
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