Advances in Preclinical Research on Drug Resistance Overcoming Strategies of Anti-HER2-Positive Breast Cancer Targeted Therapy
ZHU Yun-fang1, NIE Xu-yang1, GAO Jing-lin1, SUN Ya-qi1, FENG Zhang-ying1, WANG Ming-xia1,2*
1. Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China; 2. Hebei Provincial Key Laboratory of Tumor Microenvironment and Drug Resistance, Shijiazhuang 050011, China
Abstract：Overexpression of human epidermal growth factor receptor type 2 (HER2) is one of the important factors for poor prognosis of breast cancer patients. In recent years, HER2-targeted drugs have significantly improved the prognosis and prolonged survival of HER2-positive breast cancer patients, but primary drug resistance or acquired drug resistance during treatment will eventually lead to disease progress and even metastasis. At present, the research on the drug resistance overcoming strategy of anti-HER2 tumor drugs is not perfect. The increasing exploration on the drug resistance mechanism will aid in the identification and screening of therapies to promote the development of more new drugs. Therefore, this paper summarizes the latest research progress in drug resistance overcoming strategies of typical drugs for anti-HER2-positive breast cancer targeted therapy, in order to provide a reference for clinical development of effective strategies or personalized treatment plans to deal with drug resistance.
朱鋆芳, 聂旭阳, 高敬林, 孙亚棋, 冯章英, 王明霞. 抗HER2阳性乳腺癌靶向治疗药物耐药策略的临床前研究进展[J]. 中国药学杂志, 2023, 58(7): 553-559.
ZHU Yun-fang, NIE Xu-yang, GAO Jing-lin, SUN Ya-qi, FENG Zhang-ying, WANG Ming-xia. Advances in Preclinical Research on Drug Resistance Overcoming Strategies of Anti-HER2-Positive Breast Cancer Targeted Therapy. Chinese Pharmaceutical Journal, 2023, 58(7): 553-559.
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2023, Vol. 58 
