Abstract：OBJECTIVE To evaluate the safety, efficacy and economics of olaparib in the treatment of patients with advanced ovarian cancer using rapid health technology assessment and provide evidence-based support for its clinical drug use. METHODS Relevant Chinese and English databases were searched systematically. Two researchers independently screened the literature, extracted the data, evaluated the quality and performed a comprehensive analysis according to the inclusion and exclusion criteria, and finally the results were summarized and analyzed by the method of qualitative description. RESULTS A total of 7 systematic reviews/Meta analyses and 9 pharmacoeconomic studies were included. The results showed that compared with conventional chemotherapy, olaparib had a lower incidence of adverse reactions in patients with advanced ovarian cancer. Compared with placebo, there were some mild or moderate adverse reactions, but they were easy to control. Olaparib could prolong PFS in patients compared with placebo and conventional chemotherapy, and it is worth noting that BRCA-positive patients have more clinical benefits. None of the included pharmacoeconomic studies showed olaparib advantages. CONCLUSION Olaparib has good safety and efficacy in the treatment of platinum-sensitive recurrent ovarian cancer. In the future, it is necessary to carry out its pharmacoeconomic research in China.
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2023, Vol. 58 
