Abstract：OBJECTIVE To explore the characteristics of adverse reactions related to immune checkpoint inhibitors, and to provide reference for rational use of drugs. METHODS The adverse reaction cases related to immune checkpoint inhibitors reported in our hospital from January 2020 to April 2022 for analysis and re-evaluation were summarized Summarize the adverse reaction cases related to immune checkpoint inhibitors reported in our hospital from January 2020 to April 2022 for analysis and re-evaluation. RESULTS The 25 immune checkpoint inhibitor-related adverse reactions involved camrelizumab (8 cases), sintilimab (6 cases), tislelizumab (4 cases), durvalumab (3 cases), pembrolizumab (3 cases) and nivolumab (1 case). Among them, 13 cases (52%) were severe and 12 cases (48%) were normal. Among the 25 cases reported, there were 19 males and 6 females, the youngest age was 26 years old, the oldest age was 81 years old, and the average age was (62.40±15.38) years old. Primary diseases include lung cancer, bone tumor, esophageal cancer, bladder cancer, liver cancer and pancreatic cancer. The main clinical manifestations of adverse reactions were immune-related pneumonia, endocrine toxicity and cardiotoxicity. The occurrence time of ADR ranged from the day of administration to 329 days after the first administration. CONCLUSION Clinical attention should be paid to the safety of immune checkpoint inhibitors. Only by properly managing the adverse reactions related to immunotherapy can tumor immunotherapy be better achieved.
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2022, Vol. 57 
