1. School of Pharmacy, Harbin University of Commerce, Harbin 150076, China; 2. Key Laboratory for Drug Research on Prevention and Treatment of Geriatric Diseases of Heilongjiang Province, Harbin 150076, China; 3. School of Pharmacy, Harbin Medical University, Harbin 150081, China
Abstract：In recent years, in order to improve the bioavailability and bioactivity of emodin, researchers have modified its structure to obtain many emodin derivatives.In this paper, the bioactivities of 79 emodin derivatives including quaternary ammonium salts, quaternary phosphonium salts, methylated salts, glycosides and metal complexes were reviewed by referring to and sorting out relevant literatures domestic and overseas in recent years.The biological activities of most of the derivatives revolve around antitumor activity in vitro, and the other derivatives involve anti-mosquito activities, free radical scavenging, anti-Staphylococcus aureus and anti-tobacco mosaic virus, etc.This review provides reference for the research on the structure-activity relationship of emodin and the development of emodin drugs.
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2022, Vol. 57 
