Abstract：As a treasure of the Chinese nation, traditional Chinese medicine has a wide variety of active ingredients and extensive clinical applications. The development and utilization of Chinese medicinal materials has been a hot research topic, and microbial transformation is a hot topic in the modern development of Chinese medicine. As a widely used, safe and reliable strain, Aspergillus niger secrets various enzymes including esterase, glycosidase, hydroxylase, etc, which can cause hydroxylation, dehydroxylation, methylation,demethylation, carbonylreduction, and deglycosylation of chemical components in traditional Chinese medicine, thereby forming active compounds or drug intermediates with novel structures, providing new development ideas for the research of chemical components of Chinese medicine. This manuscript summarizes the research progress on the transformation and the reactive positions of effective chemical components in Chinese medicine by enzymes produced by Aspergillus niger as a fermentation strain, in order to further reveal the principle of the fermentation of Chinese medicine by Aspergillus niger.
吴德超, 赵正权, 李运芝, 何方丽, 曲扬. 黑曲霉转化中药化学成分研究进展[J]. 中国药学杂志, 2022, 57(14): 1153-1160.
WU De-chao, ZHAO Zheng-quan, LI Yun-zhi, HE Fang-li, QU Yang. Research Progress on the Chemical Constituents of Traditional Chinese Medicine Transformed by Aspergillus niger. Chinese Pharmaceutical Journal, 2022, 57(14): 1153-1160.
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2022, Vol. 57 
