Construction of Information Bank of Chemical Components in Isatidis Radix
NIE Li-xing1, WANG Xin-ping2, HUANG Lie-yan1, QIAN Xiu-yu3, LI Xiang4*, KANG Shuai1*, DAI Zhong1, MA Shuang-cheng1
1. National Institutes for Food and Drug Control, Beijing 100050, China; 2. Hebei University of Chinese Medicine, Shijiazhuang 050000, China; 3. Chinese Pharmaceutical Association, Beijing 100050, China; 4. Department of Pharmacy, Medical Supplies Center of the PLA General Hospital, Beijing 100048, China
Abstract：OBJECTIVE Isatidis Radix is the dried root of Isatis indigotica Fortune of Cruciferae. As a representative traditional Chinese medicine for heat-clearing and detoxification, Isatidis Radix and its preparations are widely used in the prevention and treatment of all kinds of colds and have played an active role in the prevention and treatment of SARS, H1N1 and COVID-19. Although the chemical ingredient of Isatidis Radix has been studied deeply, there is no information bank, website or literature that can comprehensively query the information of all compounds at home and abroad, which is not conducive to the development of related research. So establishment of the chemical composition information bank is in need. METHODS According to the category of chemical ingredients, the Chinese and English names, molecular formulas, exact molecular weights, structural formulas and references of nearly 400 chemical components in Isatidis Radix were comprehensively sorted out, and the chemical composition information bank of Isatidis Radix was constructed. RESULTS By September 2020, a total of 392 compounds in 17 categories had been extracted, isolated and identified from Isatidis Radix. CONCLUSIONT The established chemical composition information bank can provide the basis for the separation and identification of chemical components, quality control, material basis mining, network pharmacology research and so on.
聂黎行, 王馨平, 黄烈岩, 钱秀玉, 李翔, 康帅, 戴忠, 马双成. 板蓝根化学成分信息库的构建[J]. 中国药学杂志, 2022, 57(6): 428-452.
NIE Li-xing, WANG Xin-ping, HUANG Lie-yan, QIAN Xiu-yu, LI Xiang, KANG Shuai, DAI Zhong, MA Shuang-cheng. Construction of Information Bank of Chemical Components in Isatidis Radix. Chinese Pharmaceutical Journal, 2022, 57(6): 428-452.
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