Protective Mechanism of Caveolin-1 Regulating Neurovascular Unit in Cerebral Ischemia Injury
XIE Qian, MA Rong, WANG Jian*, CHEN Hai, LI Hong-yan, LI Yong, REN Mi-hong
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Systematic Research of Distinctive Chinese Medicine Resources in Southwest China, Chengdu 611137, China
Abstract：The latest study shows that caveolin-1 is expressed in the central nervous system, which is close to contact the occurrence and development of ischemic stroke and participants in protecting the neurovascular unit (NVU) against cerebral ischemia injuries. In addition, caveolin-1 also regulates the proliferation and the differentiation of neurons, the permeability and the function of the blood-brain barrier (BBB). Through the literature, we were found find that the caveolin-1 has high relevance to the major structure of the neurovascular unit (neuron and blood-brain barrier). Caveolin-1 holds the function of regulating neuron and blood brain barrier. What′s more, caveolin-1 can foresee the development of disease, making us find treatment early. And, many drugs can protect the brain and improve cerebral ischemia injuries through caveolin-1 and other pathways. It suggests that caveolin-1 is a potential target for remodeling neurovascular unit and treating for stroke. It is necessary to give consideration to caveolin-1 which might be an important value in the diagnosis and treatment of ischemic stroke.
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