Abstract：OBJECTIVE To optimize the best microneedle condition for transdermal absorption of cinnamaldehyde liposomes using orthogonal experiments combined with optical coherence tomography (OCT), and then provide a reference for cinnamaldehyde as a transdermal preparation for skin photoaging. METHODS The orthogonal experiment was carried out with cumulative transdermal penetration in 12 h and the recovery of skin within 1 h as indicators, the effects of microneedle length, action time and force were investigated on the permeability of cinnamaldehyde liposomes,and then the optimal microneedle conditions was selected. RESULTS The optimal microneedle condition was 250 μm, 5 N, 2 min. Under this condition, the cumulative penetration of the skin was higher, and the skin recovery degree was the strongest within 60 min. The comprehensive score of the two indicators was the highest. CONCLUSION This condition is credible and can make a reference for multiple ways of joint penetration promotion for which was selected on the basis of comprehensive consideration of the effectiveness and safety of microneedle.
杨海菊, 黄嘉怡, 杨艳玲, 李花花, 刘彩凤, 白洁. 正交实验结合OCT优选桂皮醛脂质体透皮的最佳微针条件[J]. 中国药学杂志, 2021, 56(9): 738-743.
YANG Hai-ju, HUANG Jia-yi, YANG Yan-ling, LI Hua-hua, LIU Cai-feng, BAI Jie. Optimization of the Optimal Microneedle Condition for Transdermal Cinnamaldehyde Liposomes Processed with Orthogonal Test Combined with OCT Method. Chinese Pharmaceutical Journal, 2021, 56(9): 738-743.
ZHOU L, YAN H B. Effect of cinnamic aldehyde on expression of MMP-1, MMP-3 and MAPK signal in human dermal fibroblasts after UVA irradiation[J]. Chin J Dermatovenereol(中国皮肤性病学志), 2015,(2):114-117.
[2]
GAO Y,ZHENG M C,DU S Y,et al. Preparation technology of cinnamaldehyde liposomes [J]. J Tianjin Univ Tradit Chin Med(天津中医药大学学报),2019,38(2):180-185.
[3]
XIA X,GAO W Y,LIU X Y,et al. Effect of metallic arraymicroneedle pretreatment on ramosetron hydrochloride paches in transdermal drug delivery [J]. Chin Pharm J(中国药学杂志), 2019,54(2):105-109.
[4]
MENG L J,QIAO J X,LIN P T,et al. Microneedle percutaneous drug delivery system, wound repair and pharmacology evaluation [J]. Chin Pharm J(中国药学杂志),2017,52(6):434-437.
[5]
GUO T, LU J Y, ZHAO J H,et al. Effects of microneedle combining nanostructured lipid carriers in transdermal delivery for Aconitum sinomontanum [J]. Chin J Tradit Chin Med Pharm(中华中医药杂志),2018,33(5):432-436.
[6]
ZHAN H H,HUANG Y C,MA F S. Research progress in the evaluation methods of microneedles puncture performance [J]. Chin Pharm J(中国药学杂志),2018,53(22):1890-1895.
[7]
LI Z, SONG Y L, LIN J, et al. The application progress of optical coherence tomography in the evaluation of the atherosclerotic plaques [J]. Chin J Stroke (中国卒中杂志),2018,13(8):877-880.
[8]
CUI Y H, MO Y J, ZHANG Q, et al. Microneedle-assisted percutaneous delivery of paeoniflorin-loaded ethosomes [J]. Molecules,2018, 23(12):115-130.
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