Abstract：To analyze the quality control technologies and research of polysaccharides in recent years. By searching the domestic and international literatures and practical experiences in recent years, a comprehensive integrated progress was collated and induced. Polysaccharide drugs have complex structures and their quality control is difficult. The quality control of polysaccharides should be carried out from three aspects: qualitive test, quantitative test, and safety test. Various technologies and methods such as infrared spectroscopy technology, multi-angle laser light scattering, ion chromatography, liquid chromatography, and nuclear magnetic resonance techniques should be used comprehensively to control the physical properties, molecular weight distribution, sugar composition and sugar structure, content, impurity control, and safety of polysaccharide drugs.
王悦, 范慧红. 多糖类生化药物的质控策略与质控技术研究进展[J]. 中国药学杂志, 2021, 56(1): 8-12.
WANG Yue, FAN Hui-hong. Quality Control Strategies and Research Progress in Quality Control Technology of Polysaccharide Biochemical Drugs. Chinese Pharmaceutical Journal, 2021, 56(1): 8-12.
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2021, Vol. 56 
