Advances in Research on Bioactivity and Biosynthesis of 2-(2-Phenylethyl) Chromones
XIAO Meng-jun1, GAO Zhi-hui1*, WEI Jian-he1,2*
1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China; 2. Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine & Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haikou 570311, China
Abstract：2-(2-Phenylethyl) chromones are only distributed in a few plant species and have many bioactivities such as neuroprotection, antibacterial and anti-inflammatory effects. They are the characteristic and main active components of agarwood. They are expected to have broad medicinal application value. In this paper, the research progress of the biological activities such as neuroprotective activity, anti-tumor cytotoxic activity, antibacterial activity and anti-inflammatory activity, as well as the structure-activity relationship and biosynthetic pathway of 2-(2-phenethyl) chromone compounds were reviewed and prospected. It provides a reference for screening the pharmaceutical 2-(2-phenethyl) chromone compounds and analyzing their biosynthetic pathways. Some problems in the current biosynthesis researches are also pointed out here.
肖梦君, 高志晖, 魏建和. 2-(2-苯乙基)色酮类化合物的生物活性及其生物合成研究进展[J]. 中国药学杂志, 2019, 54(23): 1909-1918.
XIAO Meng-jun, GAO Zhi-hui, WEI Jian-he. Advances in Research on Bioactivity and Biosynthesis of 2-(2-Phenylethyl) Chromones. Chinese Pharmaceutical Journal, 2019, 54(23): 1909-1918.
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2019, Vol. 54 
