哈尔滨商业大学, a. 国家教育部抗肿瘤天然药物工程研究中心;b. 药学院药物工程技术研究中心,哈尔滨 150076
Research Progress of Receptors of Plant Polysaccharides
JI Chen-fenga,b, CHEN Jin-ruib, ZHANG Zi-yib
a. Engineering Research Center of Natural Anticancer Drugs, Ministry of Education;b. Engineering Research Center for Medicine, College of Pharmacy, Harbin University of Commerce, Harbin 150076, China
Abstract：Receptors of plant polysaccharides and their signaling pathways have become a hotspot of polysaccharide activity research. As immunomodulators, polysaccharides have attracted much attention due to their immunomodulatory effects mediated by cell surface receptors. Polysaccharide receptors mainly include C-type lectin receptor family, mannose receptor family (MR), Toll-like receptor family (TLR), complement receptor 3 (CR3), scavenger receptor and so on, and these receptors play an important role in the recognition between polysaccharides and cells, which is closely related to polysaccharides activities, such as enhancing cellular immune function, regulating the secretion of cytokines, having immunomodulatory and antineoplastic effects. In this paper, polysaccharide receptors types, biological functions and signal transduction pathways are reviewed, it will be helpful to elucidate the pharmacological activity mechanism of plant polysaccharides and provide theoretical reference for the comprehensive development of polysaccharide drugs.
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2019, Vol. 54 
