Structure of the Conjugated Linoleic Acid-Paclitaxel Conjugate Self-Assembled Nanoparticles
ZHENG Xiu-chai1a,1b, XU Mei-qi1a,1b, LIU Man1a,1b, ZHONG Ting1a,1b, HAO Yan-li1a,1b, ZHANG Shuang1a,1b, LI Zhan-tao1a,1b, LI Zhuo-yue1a,1b, DUAN Xiao-chuan1a,1b, FENG Zhen-han1a, WANG Jing-ru1a,1b, LI Hui1a, WANG Guang-xue1b, LIAO Ai1b, ZHANG Hua2, LIU Bi-lin3, ZHANG Xuan1a,1b*
1a. Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems;1b. Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; 2. Key Laboratory of Xinjiang Phytomedicine Resources and Utilization of Ministry of Education, School of Pharmacy, Shihezi University, Shihezi 832000, China; 3. College of Pharmaceutical Engineering, Chongqing Chemical Industry Vocational College, Chongqing 401228, China
Abstract：OBJECTIVE To prepare, the conjugated linoleic acid-paclitaxel conjugate self-assembled nanoparticles (CLA-PTX NPs) by nanoprecipitation. METHODS The Dynamic light scattering, nuclear magnetic resonance spectroscopy, raman spectroscopy, fourier transform infrared spectroscopy and nitrogen element distribution of CLA-PTX NPs were studied. RESULTS The hydroxyl groups (C-4 and C-10 of PTX) and the acetyl groups (C-1 and C-7 of PTX) were on the surface of CLA-PTX NPs, CLA carbon chain, the benzene ring (C-2 and C-3′ of PTX) and the amide bond (C-3′ of PTX) were inside the CLA-PTX NPs. CONCLUSION It is speculated that the self-assembly of CLA-PTX is that the non-polar CLA carbon chain spontaneously aggregates inward due to hydrophobic interaction, and the hydrophilic oxygen-containing groups of PTX (hydroxyl group and carbonyl group) are on the surface of the nanoparticle to form nanoparticles.
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2019, Vol. 54 
