Optimization of Preparation Process of Fast-Dissolving Microneedles by Box-Behnken Method
YAO Ming-jie1, ZHAO Feng1*, MA Yin-ling1,2, WANG Yi-meng1, DU Qing1*
1. Department of Pharmaceutics, School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China; 2. Department of Pharmacy, Hebei General Hospital, Shijiazhuang 050051, China
Abstract：OBJECTIVE To optimize the formulation and preparation process of fast-dissolving PVP microneedles, and provide a high-quality carrier for PVP drug-loaded microneedle research. METHODS On the basis of single factor, the needle tips dissolution time and insertion ratio were used as the evaluation indexes, and the optimal preparation process of microneedle was optimized by Box-Behnken method. RESULTS From the single factor test and the Box-Behnken test, it was known that the optimum preparation conditions were as follows: the needle tip concentration was 0.70 g·mL-1, the temperature was 40 ℃, and the humidity was 40%. The microneedle height was 600 μm, the width was 200 μm, the pitch was 500 μm, quadrangular pyramid. The area of the microneedle patch was 0.56 cm2, the dissolution time in water was (41.00±3.74)s, and the insertion ratio was (93.19±5.25)%. CONCLUSION The PVP fast-dissolving microneedles can be prepared simply and conveniently by the Box-Behnken method, which provides a reference for the preparation of further drug-loaded microneedles.
姚明杰, 赵锋, 马银玲, 汪祎梦, 杜青. Box-Behnken法优化快速溶解性微针的制备工艺[J]. 中国药学杂志, 2019, 54(20): 1677-1684.
YAO Ming-jie, ZHAO Feng, MA Yin-ling, WANG Yi-meng, DU Qing. Optimization of Preparation Process of Fast-Dissolving Microneedles by Box-Behnken Method. Chinese Pharmaceutical Journal, 2019, 54(20): 1677-1684.
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2019, Vol. 54 
