保留指数原理在中药材农药残留快速筛查和定量分析中的研究进展

谭鹏, 万渝平, 文永盛, 包晓明, 张定堃, 许莉

中国药学杂志 ›› 2019, Vol. 54 ›› Issue (20) : 1637-1641.

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中国药学杂志
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中国药学杂志 ›› 2019, Vol. 54 ›› Issue (20) : 1637-1641. DOI: 10.11669/cpj.2019.20.001
综 述

保留指数原理在中药材农药残留快速筛查和定量分析中的研究进展

  • 谭鹏1, 万渝平1, 文永盛1, 包晓明2, 张定堃3, 许莉1*
作者信息 +

Research Progress of Retention Index Principle in Rapid Screening and Quantitative Analysis of Pesticide Residues in Chinese Herbal Medicines

  • TAN Peng1, WAN Yu-ping1, WEN Yong-sheng1, BAO Xiao-ming2, ZHANG Ding-kun3, XU Li1*
Author information +
文章历史 +

摘要

农药残留影响到了中药的质量安全和国际声誉,逐渐受到民众和监管部门的广泛关注。随着人们对高品质绿色中药产品的需求增多,监管部门对中药产品农药残留的检测频率和检测种类也将明显增多,当务之急是建立具有快速、简便、高通量和低检测成本等特点的农药残留测定方法。笔者概述了中药材中农药残留分析的研究现状,总结了中药材农药残留测定面临的困难,介绍了保留指数原理应用于中药材农药残留分析的优势。重点介绍了保留指数原理结合Smart Database-Pesticides database数据库应用于八角茴香中12种拟除虫菊酯类农药化合物的测定,川芎中74种农药化合物的测定和西洋参中130种农药化合物测定的研究进展。本研究的目的是让保留指数原理在中药材农药残留快速分析中得到更多普及应用。

Abstract

The pesticide residues in traditional Chinese herbal medicines have seriously affected its safety of quality and international reputation, and have been widely concerned by the public and regulatory authorities. With the increasing demand for high-quality green Chinese medicine products, the frequency of quantitative determination of pesticide residues in traditional Chinese medicine products by the regulatory authorities will also increase significantly. It is imperative to establish a series of quantitative methods for pesticide residue analysis that are fast, simple, high-throughput, and low-cost. This paper mainly summarized the research status of pesticide residues analysis in Chinese herbal medicines, summarized the difficulties encountered in the analysis of pesticide residues in Chinese herbal medicines, and introduced the advantages of the retention index principle applied to the analysis of pesticide residues in Chinese herbal medicines. This paper highlights the research progress of retention index principle combined with the Smart Database-Pesticides database applied to three exemplary examples, including: the quantitative determination of 12 pyrethroid pesticide compounds in Anisi Stellati Fructus, the quantitative determination of 74 pesticide compounds in Chuanxiong Rhizoma, and quantitative determination of 130 pesticide compounds in Panacis Quinquefolii Radix. The purpose of this paper is to make retention index principle more popular in the rapid analysis of pesticide residues in traditional Chinese herbal medicines.

关键词

保留指数 / 农药残留 / 中药 / 快速筛查 / 靶向定量 / 气相色谱-三重四极杆质谱联用技术

Key words

retention index / pesticide residue / traditional Chinese herbal medicine / rapid screening / targeted quantification / GC-QQQ-MS/MS

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谭鹏, 万渝平, 文永盛, 包晓明, 张定堃, 许莉. 保留指数原理在中药材农药残留快速筛查和定量分析中的研究进展[J]. 中国药学杂志, 2019, 54(20): 1637-1641 https://doi.org/10.11669/cpj.2019.20.001
TAN Peng, WAN Yu-ping, WEN Yong-sheng, BAO Xiao-ming, ZHANG Ding-kun, XU Li. Research Progress of Retention Index Principle in Rapid Screening and Quantitative Analysis of Pesticide Residues in Chinese Herbal Medicines[J]. Chinese Pharmaceutical Journal, 2019, 54(20): 1637-1641 https://doi.org/10.11669/cpj.2019.20.001
中图分类号： R284   

参考文献

[1] MA S C, JIN H Y, LIU L N, et al. Risk control of exogenous harmful residues in traditional Chinese medicines [J]. Chin Pharm J (中国药学杂志), 2015, 50(2):99-103.
[2] JIN H Y, WANG Y, LIU L N, et al. Promoting the standard construction of quality and safety of traditional Chinese medicine with risk control as the core [J]. Drug Stand China (中国药品标准), 2017, 18(6):408-410.
[3] JIN C L,SHI Z H. Simultaneous determination of 155 pesticide residues in four kinds of Chinese herbal medicines by DSPE-SPELC-MS/MS [J]. Chin J Anal Lab (分析试验室), 2012, 31(5):84-92.
[4] WANG Y, JIN H Y, JIANG Y B, et al. Census of pesticide residues and suggestions for control in traditional Chinese medicine [J]. China J Chin Mater Med (中国中药杂志), 2014, 39(5):807-811.
[5] Ch.P(2015) Vol Ⅰ(中国药典2015年版.一部) [S]. 2015.
[6] XU C Q. Export status, constraints and upgrade ways of Chinese traditional medicine products [J]. Practice in Foreign Economic Relations and Trade (对外经贸实务), 2016, 36(10):54-56.
[7] KANG C Z, GUO L P, ZHOU T, et al. Discussion on present situation of study on pesticide residues in Chinese herbal medicines [J]. China J Chin Mater Med (中国中药杂志), 2016, 41(2):155-159.
[8] FU Q Z,LIN H B,LIN J Q, et al. Research progress of pesticide residue in Chinese herbal medicine causes and prevention measures [J]. Lishizhen Med Mater Med Res (时珍国医国药), 2014, 25(4):925-927.
[9] WANG L L, XIA H L. Characteristics of pesticide residues in Chinese herbal medicines in China [J]. Chin Tradit Herb Drugs (中草药), 2007, 38(3):471-474.
[10] Ch.P(2015) Vol Ⅳ(中国药典2015年版.四部)[S]. 2015:212-224.
[11] LIU K K, XIANG H, LI Y, et al. Determination of 15 pyrethroid pesticide residues in 8 plant extracts by GC-MS/MS [J]. Chin J Anal Lab (分析试验室), 2014, 33(8):930-935.
[12] DU G, XIAO Y, YANG H R, et al. Rapid determination of pesticide residues in herbs using selective pressurized liquid extraction and fast gas chromatography coupled with mass spectrometry [J]. J Sep Sci, 2012, 35(15):1922-1932.
[13] TAHA S M, GADALLA S A. Development of an efficient method for multi residue analysis of 160 pesticides in herbal plant by ethyl acetate hexane mixture with direct injection to GC-MS/MS [J]. Talanta, 2017, 70(174):767-779.
[14] CHEN L, SONG F, LIU Z, et al. Study of the ESI and APCI interfaces for the UPLC-MS/MS analysis of pesticides in traditional Chinese herbal medicine [J]. Anal Bioanal Chem, 2014, 406(5):1481-1491.
[15] GAO Y, LIU W, XIONG H, et al. Detection pesticide residues of Salviae Miltiorrhizae Radix et Rhizoma in national survey on Chinese material medicare sources [J]. Chin J Exp Tradit Med Form(中国实验方剂学杂志), 2018, 24(17):74-79.
[16] WU J L, ZHAN X P, ZOUY H, et al. Investigation of organophosphorous insecticides residue in Chinese crude drugs [J]. China J Chin Mater Med(中国中药杂志), 2007, 32(9):798-800.
[17] TAN P, ZHANG H Z, XU L, et al. Development and application of a simultaneous quantitative analysis method of 58 pesticide residues in Anemarrhena asphodeloides based on QuEChERS-GC-QQQ-MS/MS [J]. Chin Tradit Herb Drugs (中草药), 2018, 49(14):3397-3405.
[18] LIANG C, LIUY R, ZHAO C J, et al. Multi-residue determination of 11 pesticides in Shengmaiyin prescription by gas chromatography [J]. China J Chin Mater Med (中国中药杂志), 2011, 36(8):997-1000.
[19] ZHANG Y M. Organic pesticide residue testing in the Huoxiangzhengqi Pills and herbs [J]. Heilongjiang Med J(黑龙江医药), 2009, 22(1):38-40.
[20] KOVATS E. Gas-chromatographische charakterisierung organischer verbindungen. Teil 1: retentionsindices aliphatischer halogenide alkohole [J]. Helv Chim Acta, 1958, 41: 1915-1932.
[21] ZHANG J, FANG A, WANG B, et al. iMatch: a retention index tool for analysis of gas chromatography-mass spectrometry data [J]. J Chromatogr A, 2011, 1218(37):6522-6530.
[22] KOO I, SHI X, ZHANG X, et al. iMatch2: compound identification using retention index for analysis of gas chromatography-mass spectrometry data [J]. J Chromatogr A, 2014, 1337: 202-210. DOI: 10.1016/j.chroma.2014.02.049.
[23] KUMARI S, STEVENS D, KIND T, et al. Applying in-silico retention index and mass spectra matching for identification of unknown metabolites in accurate mass GC-TOF mass spectrometry [J]. Anal Chem, 2011, 83 (15):5895-5902.
[24] GUO W, LU Y, ZHENG X M. The predicting study for chromatographic retention index of saturated alcohols by MLR and ANN [J]. Talanta, 2000, 51(3):479-488.
[25] MIHALEVA V V, VERHOEVEN H A, HALL R D, et al. Automated procedure for candidate compound selection in GC-MS metabolomics based on prediction of Kovats retention index [J]. Bioinformatics, 2009, 25 (6):787-794.
[26] TAN P, ZHANG H Z, ZHANG D K, et al. New strategy for analysis of pesticide residues in Chinese herbal medicines: development of a GC-QQQ-MS/MS quantitative method of pyrethroid pesticides in Anisi Stellati Fructus based on retention index [J]. Chin J Pharm Anal (药物分析杂志), 2019, 39(7):1256-1266.
[27] FENG J. Development of optically active pyrethroid insecticides [J]. Chin J Pestic (农药), 2000,19(2):1-6.
[28] TA N, LI X, SUN C, et al. Diastereomeric and enantiomeric separation of pyrethroid pesticides [J]. Chin Envi Sci (中国环境科学), 2006, 26(1):87-90.
[29] LI C Y, ZHANG Z C, ZHANG L, et al. Research progress on chiral separation of pyrethroid pesticides [J]. Mod Agrochem (现代农药), 2006, 5(5):1-5.
[30] LIU X, ZHON H N, YANG X M, et al. Determination of the residues of cypermethrin and fenvalerate in nine medical materials [J]. Lishizhen Med Mater Med Res (时珍国医国药), 2006, 27(2):154-155.
[31] ZHAO M Y, WANG Q, YANG X W. Determination of pyrethroids pesticide residues in Fructus Evodiae as traditional Chinese medicine [J]. Chin J Pharm Anal (药物分析杂志), 2007, 27(9):1344-1347.
[32] TAN P, WEI X C, ZHANG H Z, et al. A novel and practical method for rapid screening and quantitative analysis of 130 pesticide residues in herbal medicines based on Kovats retention index principle: an exemplary study using Panacis quinquefolii radix [J]. Anal Meth, 2019, DOI: 10.1039/C9AY01310E.
[33] QIAN Y X. The influence of foreign new rural residue standards on Chinese medicine export and its countermeasures [D]. Shenyang: Shenyang Pharmaceutical University, 2014:36.
[34] WU Y X, TIAN K, YU X Y, et al. Dilemma and reform on collaborative governance of Chinese herbal pieces [J]. Chin Tradit Herb Drugs (中草药), 2019, 50(4):1027-1032.
[35] CAI Y, HU H, NI J Y, et al. Development of quality traceability system of traditional Chinese medicine [J]. China J Chin Mater Med (中国中药杂志), 2013, 38(22):3829-3833.
[36] WANG Y, JIN H Y, SUI H X, et al. Analysis of pesticide residues in wolfberry and dietary exposure risk assessment [J]. Chin Pharm J (中国药学杂志), 2018, 53(3):182-186.

基金

四川省科技厅项目资助(2019YJ0640);成都市科技局项目资助(2016-HM01-00312-SF,2018-YF05-01277-SN)
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