Appropriate Use of Non-steroidal Anti-inflammatory Drugs during the Perioperative Period: a Retrospective Multicenter Study
WANG Rong-rong1, RAO Yue-feng1*,YU Zhen-wei2, YAO Di-fei3, ZHAO Lu-ping4, ZHU Yan-yan5, MA Li-li6, LU Xiao-yang1
1. The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China; 2. Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China; 3. The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; 4. Dongyang People′s Hospital, Dongyang 322100, China; 5. Lishui Central Hospital, Lishui 323000, China; 6. Ningbo Medical Center Lihuili Hospital, Ningbo 315041, China
Abstract：OBJECTIVE To evaluate the appropriateness of nonsteroidal anti-inflammatory drugs (NSAIDs) used in the perioperative period. METHODS This was a retrospective multicenter study with three stages: ①characterization of the application of NSAIDs through questionnaires; ②establishment of an expert group and development of the standard for prescription evaluation; ③random enrollment of cases using NSAIDs during the perioperative period from October 2016 to March 2017 and evaluation of prescriptions. RESULTS The study was conducted in 16 tertiary-care hospitals and included 960 cases. NSAIDs were commonly used in 15 hospitals (93.8%) during the perioperative period. Flurbiprofen axetil injection, parecoxib sodium injection and celecoxib capsule were NSAIDS with the top three expenses. Ten (62.5%) hospitals did not routinely intervene for the irrational use of NSAIDs, and only two (12.5%) hospitals established the regulatory regime of NSAIDs.The overall irrational rate was 23.3% (n=224). Too long continuous medication duration and inappropriate combination of NSAIDs were the main problems, involving 98 cases (10.2%) in 10 hospitals and 76 cases (7.9%) in 11 hospitals, respectively. Other problems were: 26 cases (2.7%) used drugs beyond contraindication, and 24 cases (2.5%) administrated drugs in irrational route.CONCLUSION NSAIDs are widely used in the perioperative period. Lack of regulatory regime, insufficient clinical intervention and irrational prescriptions are the current status of NSAIDs usage. Therefore, it is necessary to take powerful measures and effective pharmaceutical intervention to improve the use of NSAIDs.
王融溶, 饶跃峰, 俞振伟, 姚迪翡, 赵璐萍, 朱延焱, 马俐丽, 卢晓阳. 围手术期非甾体抗炎药合理使用情况的多中心回顾性研究[J]. 中国药学杂志, 2019, 54(13): 1104-1108.
WANG Rong-rong, RAO Yue-feng,YU Zhen-wei, YAO Di-fei, ZHAO Lu-ping, ZHU Yan-yan, MA Li-li, LU Xiao-yang. Appropriate Use of Non-steroidal Anti-inflammatory Drugs during the Perioperative Period: a Retrospective Multicenter Study. Chinese Pharmaceutical Journal, 2019, 54(13): 1104-1108.
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2019, Vol. 54 
