Characterization of Physicochemical Properties of HPMC from Different Manufacturers and Their Effect on Sustained Release
ZHU Yu-ping1, YANG Zhao2*, ZHANG Yan2, ZHOU Xing-tong2, ZHANG Shuai-hua1
1. Department of Pharmaceutical Analysis, School of Pharmacy, Qingdao University, Qingdao 266021, China;
2. Qingdao Institute for Food and Drug Control, Qingdao 266071, China
OBJECTIVE To investigate the physicochemical properties of hydroxypropyl methylcellulose(HPMC)produced by different manufacturers, and to establish a link between the physicochemical properties of HPMC and its sustained release effect, which can provides a theoretical basis for further rational application. METHODS The physicochemical properties of HPMC collected from different manufacturers, such as particle size distribution, bulk density, physical form, crystallinity and degree of substitution were characterized by laser particle size analyzer, bulk density measuring device, scanning electron microscope, X-ray diffractometer and gas chromatography, respectively. Then, the HPMC from different manufacturers were pressed into sustained release tablets, and the sustained release effect was compared by the dissolution curve. RESULTS The physicochemical properties of HPMC produced by different factories are different, which are manifested in different particle sizes,different bulk densities, different physical shapes, whether there are differences in crystallization peaks and the content of hydroxypropoxy groups, and the different physicochemical properties directly lead to the difference of sustained release effects. CONCLUSION The study of physicochemical properties of HPMC can better control its quality and use it more widely.
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ZHU Yu-ping, YANG Zhao, ZHANG Yan, ZHOU Xing-tong, ZHANG Shuai-hua. Characterization of Physicochemical Properties of HPMC from Different Manufacturers and Their Effect on Sustained Release. Chinese Pharmaceutical Journal, 2019, 54(12): 1018-1023.
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2019, Vol. 54 
