Two dimensional liquid chromatography (2D-LC) has become an important way to achieve the separation of complex samples due to higher peak capacity, higher selectivity and better separation ability compared with one-dimensional liquid chromatography(1D-LC). 2D-LC has been developing rapidly in many fields, such as medicine, food, metabolites in vivo or in vitro and so on. This review illustrates various separation modes of 2D-LC and its applications and developments, with emphases on the research of quality control of drugs.
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LIU Zhao-xia, ZHOU Ya-nan, HE Lan, DING Li-xia. Application of Two Dimensional Liquid Chromatography in Drug Analysis. Chinese Pharmaceutical Journal, 2019, 54(12): 941-946.
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2019, Vol. 54 
