Abstract��OBJECTIVE To investigate the pharmacokinetics and tissue distribution characteristics of 7-p-TFM-FL118(7-p-trifluoromethylphenylboronic-FL118)��-cyclodextrin complex and raw 7-p-TFM-FL118 for the development of a new 7-p-TFM-FL118 formulation.METHODS Administrated orally the complex group and raw group drugs at the dose of 10 mg��kg-1(based on the content of 7-p-TFM-FL118), the concentrations of 7-p-TFM-FL118 in plasma and tissues at different time points were determined by HPLC, and their pharmacokinetic parameters and tissue distribution characteristics were compared. RESULTS The pharmacokinetics and tissue distribution results showed that, the AUC0-t and ��max of complex group increased by 7.3 times and 2.8 times respectively, tl/2 extended from 35.52 h to 53.23 h. The 7-p-TFM-FL118 concentration of the complex group was significantly increased in each tissue. After administration, a new substance appeared at 6.5-6.9 min in the chromatogram of tissues, and the complex group had a higher concentration. CONCLUTION The complex packaged by ��-cyclodextrin could enhance the oral bioavailability significantly, increase the drug concentration in tissue, change the distribution ratio slightly, and extend retention time in tissue.
���Ͽ�, ���೬, ������, ������, �Ͷ���, ���ij�, ������. 7-p-TFM-FL118-��-�������������ҩ��ѧ����֯�ֲ��о�[J]. �й�ҩѧ��־, 2019, 54(7): 576-580.
WANGMeng-ke, HONGYi-chao, XIALi-hua, FENGYa-nan, JIDong-hao, WANGWen-chao, LIQing-yong. Study on Pharmacokinetics and Tissue Distribution of a 7-p-TFM-FL118-��-Cyclodextrin Complex. Chinese Pharmaceutical Journal, 2019, 54(7): 576-580.
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2019, Vol. 54 
