Five Cases of Bisphosphonate Therapy on Children with McCune-Albright Syndrome and Literature Review
TANG Yan1, CHANG Miao-miao2, DU Bo-ran3, ZHU Hui-juan4*, MEI Dan1, FENG Kai4, YANG Hong-bo4, WANG Ou4, XING Xiao-ping4
1. Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China; 2. Department of Pharmacy, 309 Hospital of PLA, Beijing 100091, China; 3. Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China; 4. Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Abstract��OBJECTIVE To provide references for clinical rational drug use through five empirical analysis of zoledronate��s application on children with McCune-Albright syndrome.METHODS The clinical data of five children with McCune-Albright syndrome were analyzed and summarized. Literature review was conducted to analyze long-term out come of bisphosphonate therapy and factors influencing outcome of bisphosphonate therapy in fibrous dysplasia. RESULTS Bisphosphonate therapy achieved certain effects, and there were no serious adverse events occurred. CONCLUSION Bisphosphonate therapy can be used on children with McCune-Albright syndrome,the prognostic factor that influencing outcome of bisphosphonate therapy is the extent of skeletal involvement.
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TANG Yan, CHANG Miao-miao, DU Bo-ran, ZHU Hui-juan, MEI Dan, FENG Kai, YANG Hong-bo, WANG Ou, XING Xiao-ping. Five Cases of Bisphosphonate Therapy on Children with McCune-Albright Syndrome and Literature Review. Chinese Pharmaceutical Journal, 2019, 54(2): 132-136.
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