Recent Progress in Research on Reversing the Mechanism of Tumor Acquired Drug Resistance by Traditional Chinese Medicines
ZHANG Ming-yu, LI Chun-yu, LI Guo-hui*
National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Abstract��Collect and analyze recent studies on the reversal of the mechanism of tumor drug resistance by traditional Chinese medicines, and provide ideas for research on the intervention of acquired tumor resistance with traditional Chinese medicines. CNKI, Wanfang, Pubmed and other databases were searched for literature on the reversal of the mechanism of tumor drug resistance by traditional Chinese medicines and Chinese herbal compound in the past 5 years. The search terms included ��traditional Chinese medicine��, ��traditional Chinese medicine formula��, ��traditional Chinese medicine monomer��, ��traditional Chinese medicine patent prescription��, ��traditional Chinese medicine injection��, ��drug resistance, multidrug resistance��, and ��tumor��. The literatures were collated and analyzed. The interventions of traditional Chinese medicine on drug resistance of tumors mainly were regulating the expression of transporter proteins on the cell surface, inducing apoptosis, and regulating the expression of related enzymes in cells. Traditional Chinese medicine monomers and their compound preparations can reverse the multidrug resistance of tumors. The combined use of Chinese medicine preparations and chemotherapeutic drugs can significantly enhance the clinical treatment effect and reverse the drug resistance of tumors. Traditional Chinese medicines can reverse acquired tumor resistance through multiple targets, but the precise reversal mechanism remains to be further studied.
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ZHANG Ming-yu, LI Chun-yu, LI Guo-hui. Recent Progress in Research on Reversing the Mechanism of Tumor Acquired Drug Resistance by Traditional Chinese Medicines. Chinese Pharmaceutical Journal, 2018, 53(24): 2069-2073.
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2018, Vol. 53 
