Abstract��OBJECTIVE To investigate the curative effect of Shugan granule in the treatment of post-stroke depression (PSD) and effect on brain devived neurotrophic factor(BDNF) and inflammatory factors.METHODS Eighty Patients with PSD were randomly divided into control group and study group, 80 cases in each group. Besides routine treatment, control group received citalopram hydrobromide 20 mg��d-1. Study group received Shugan granule 1 bags��time-1, twice a day based on control group.8 weeks for a course of treatment. HAMD scores, BI index, BDNF and inflammatory factors levels were compared.RESULTS The total effective rate in study group was significantly higher than that in control group[71 cases,88.75% vs 61 cases, 76.25%, ��2=4.329, P<0.05]. Repeated measurement data analysis of variance showed, the overall scores of HAMD in study group were significantly lower than those in control group [Fgroup=36.541, P<0.05]. The HAMD scores of the two groups decreased with the extension of treatment time [Ftime=668.574, P<0.05].The reduction extent of HAMD score in study group was significantly higher than that in control group[Fgroup��time=18.495, P<0.05]. BI indexes and BDNF levels in study group were significantly higher than those in control group [Fgroup=48.147, 41.561, P<0.05]. BI indexes and BDNF levels of two groups increased with the extension of treatment time [Ftime=316.586, 595.864, P<0.05]. The increasing extent of BI indexes and BDNF levels in study group was significantly higher than that in control group [Fgroup��time=22.849, 10.515, P<0.05]. The overall levels of TNF-��, IL-6 and hs-CRP in study group were significantly lower than those in control group [Fgroup=117.849, 85.168, 66.763, P<0.05]. TNF-��, IL-6 and hs-CRP levels of two groups decreased with the extension of treatment time [Ftime=864.584, 697.717, 1 037.167, P<0.05]. The reduction extent of TNF-��, IL-6 and hs-CRP levels in study group was significantly higher than that in control group[Fgroup��time=31.271, 26.174, 17.585, P<0.05]. There was no significant difference in adverse reactions between the two groups [9 cases, 11.25% vs 15 cases, 18.75%, ��2=1.765, P>0.05].CONCLUSION On the basis of conventional western medicine treatment, Shugan granules can improve the degree of depression and reduce the level of inflammatory factors in patients with PSD.
����Ϫ,�ﺣ��,������,�����,ʷ��ƽ,���Ӻ�,����ƽ. ��ο��������Թ���������֢����Ч����BDNF����֢����ˮƽ��Ӱ��[J]. �й�ҩѧ��־, 2018, 53(13): 1140-1144.
LIU Xiao-xi, SUN Hai-min, SHANG Meng-meng, LI Hui-min, SHI Fu-ping, ZHANG Xing-hong, SONG Yue-ping. The Curative Effect of Shugan Granule in the Treatment of Post-stroke Depression and Effect on BDNF and Inflammatory Factors. Chinese Pharmaceutical Journal, 2018, 53(13): 1140-1144.
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