Effects of Dipyridamole on Learning and Memory Impairment in Rat with Vascular Dementia
LI Guo-liang1, ZHANG Cong2, CHEN Ling-yun3, TANG Chong3, JIANG Wei3, LU Feng-rong1, YANG Xue-mei3
1. Institute of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment; Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment, Guangzhou 510300, China; 2. Department of Pharmacy,Guangdong No.2 Provincial People��s Hospital, Guangzhou 510317, China; 3. School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China
Abstract��OBJECTIVE To investigate the protective effects of dipyridamole on learning and memory impairment of vascular dementia (VD) in rats and explore the potential mechanisms.METHODS 4-Vessel occlusion (4-VO) was performed to establish the model of VD. Spatial memory performance was examined using the Morris water maze and step-through passive avoidance tests. The mRNA and protein levels of nuclear factor (NF)-��B, tumor necrosis factor (TNF-��) and interleukin (IL)-1�� were measured by RT-PCR and Western-blot in the CA1 district of hippocampus, respectively.RESULTS Compared with vehicle-treated controls, rats treated with 4-VO spented a longer time finding the hidden platform during the acquisition trials of the Morris water maze task; this was reversed by repeated treatment with dipyridamole. In the passive avoidance test, the model rats showed decreased retention tested 24 h after initial training; this was reversed by dipyridamole. The expression of NF-��B, TNF-�� and IL-1�� levels were increased after 4-VO performed and the dipyridamole significantly reduced the release of these inflammation-related factors.CONCLUSION Dipyridamole could reverse the learning and memory impairment of VD by reducing the inflammation reaction.
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LI Guo-liang, ZHANG Cong, CHEN Ling-yun, TANG Chong, JIANG Wei, LU Feng-rong, YANG Xue-mei. Effects of Dipyridamole on Learning and Memory Impairment in Rat with Vascular Dementia. Chinese Pharmaceutical Journal, 2018, 53(9): 695-700.
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2018, Vol. 53 
