YU fan1,2, XU Li-jia1,2, WAN Wen-ting1,2, WEI Jian-he1,2*, XIAO Pei-gen1,2
1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China;
2.Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China
Shilajit, as a natural exsiting organic matter, mainly distributed in mountains area along the silk road. Shilajit mainly contains humus, as a kind of adaptogen, with pharmacological effects of anti-oxidation, anti-inflammatory, immune regulation and so on. It mainly treats urogenital diseases, digestive dysfunction and neurological diseases. The research of shilajit is still in the initial stage, and its source, composition, effective material basis and quality control of shilajit are worth further study. It is believed that after the systematic arrangement and further research, shilajit will become one of important traditional medicine.
FROLOVA L N, KISELEVA T L. Chemical composition of mumijo and methods for determining its authenticity and quality(a review)[J] . Pharm Chem J, 1996, 30(8):543-547.
[2]
GAREDEW A, FEIST M, SCHMOLZ E, et al. Thermal analysis of mumiyo, the legendary folk remedy from the Himalaya region[J] . Thermochim Acta, 2004, 417(2):301-309.
[3]
WILSON E, RAJAMANICKAM G V, DUBEY G P, et al. Review on shilajit used in traditional Indian medicine[J] . J Ethnopharmacol, 2011, 136(1):1-9.
[4]
CAO Y, GU Y, ZHAO M M, et al. Classics textual research and using situation investigation of Tibetan medicine "Zha-xun"[J] . Chin Pharm J(�й�ҩѧ��־), 2016, 51(24):4663-4669.
[5]
KIZAIBEK M. Research advances of tasmayi[J] . Chin Pharm J(�й�ҩѧ��־), 2013,48(3):443-448.
[6]
KAUR S, KUMAR P, KUMAR D, et al. Parasympathomimetic effect of shilajit accounts for relaxation of rat corpus cavernosum[J] . Am J Mens Health, 2013, 7(2):119-127.
[7]
HILL A C, FORTI P. Cave minerals of the world[M] . 2nd ed, Huntsville:National Speleological Society,1997:217-223.
[8]
ALI M, SAHRAWAT I, SINGH O. Phytochemical investigation of Shilajit[J] . Indian J Chem, 2004, 43B:2217-2222.
[9]
SCHEPETKIN I, KHLEBNIKOV A, KWON B S. Medical drugs from humus matter: focus on mumie[J] . Drug DevelopRes, 2002, 57(3):140-159.
[10]
SCHEPETKIN I A, KHLEBNIKOV A I, AH S Y, et al. Characterization and biological activities of humic substances from mumie[J] . J Agricul Food Chem, 2003, 51(18):5245-5254.
[11]
AGARWAL S P, RAJESH K, RITESH K, et al. Shilajit:a review[J] . Phytother Res Ptr, 2007, 21(5):401-405.
[12]
GHOSAL S, REDDY J P, LAL V K. Shilajit I:chemical constituents[J] . J Pharm Sci, 1976, 65(5):772-773.
[13]
GHOSAL S, SINGH S K, KUMAR Y, et al. Anti-ulcerogenic activity of fulvic acids and 4′-methoxy-6-carbomethoxybiphenyl isolated from shilajit[J] . Phytother Res, 1988, 2(4):187-191.
[14]
SALEEM A M, GOPAL V, RAFIULLAH M R M, et al. Chemical and pharmacological evaluation of karpura shilajit bhasma, an ayurvedic diurectic formulation[J] . African J Tradit Compl Alternat Med, 2006, 3(2):27-36.
[15]
Ghosal, Shibnath. Shilajit in perspective[J] . Phytother Res, 2006, 23(1):143-143.
[16]
GHOSAL S. SHILAJIT. PART IX. Chemistry of shilajit, an immunomodulatory ayurvedic rasayan[J] . Pure Appl Chem, 1990, 62(7):1285-1288.
[17]
ALHIMAIDI A R, UMAR M. Safe use of salajeet during the pregnancy of female mice[J] . J Biol Sci, 2003, 3(8):681-684.
[18]
GHOSAL S. Shilajit:its origin and vital significance[J] . Tradit Med, 1993:308-319.
[19]
MUSTHAFA M S, JAWAHAR ALI A R, HYDER ALI A R, et al. Effect of shilajit enriched diet on immunity, antioxidants, and disease resistance in macrobrachium rosenbergii(de Man) against aeromonas hydrophila[J] . Fish Shellfish Immunol, 2016, 57:293-300.
[20]
SURAPANENI D K, ADAPA S R, PREETI K, et al. Shilajit attenuates behavioral symptoms of chronic fatigue syndrome by modulating the hypothalamic-pituitary-adrenal axis and mitochondrial bioenergetics in rats[J] . J Ethnopharmacol, 2012, 143(1):91-99.
[21]
HARSAHAY M, PANDEY H K, ARYA M C, et al. Shilajit: a panacea for high-altitude problems[J] . Int J Ayurv Res, 2010, 1(1):37-40.
[22]
KNOLL J. Pharmacological basis of the therapeutic effect of (-) deprenyl in age-related neurological diseases[J] . Med Res Rev, 1992, 12(5):505-524.
[23]
WANG C, WANG Z, PENG A, et al. Interaction between fulvic acids of different origins and active oxygen radicals[J] . Sci China C Life Sci,1996, 39(3):267-275.
[24]
BHATTACHARYA S K, SEN A P, SHIBNATH G. Effects of Shilajit on biogenic free radicals[J] . Phytother Res, 1995, 9:56-59.
[25]
SAXENA N, DWIVEDI U N, SINGH R K, et al. Modulation of oxidative and antioxidative status in diabetes by asphaltum panjabinum[J] . Diabetes Care, 2003, 26(26):2469-2470.
[26]
GHOSAL S. Free radicals, oxidative stress and antioxidant defense[J] . Phytomedica, 2000, 21(1):1-8.
[27]
GOEL R K, BANERJEE R S, ACHARYA S B. Antiulcerogenic and antiinflammatory studies with shilajit[J] . J Ethnopharmacol, 1990, 29(1):95-103.
[28]
GHOSAL S, LAL J, JAISWAL A K, et al. Effects of shilajit and its active constituents on learning and memory in rats[J] . Phytother Res, 1993, 7(1):29-34.
[29]
MALEKZADEH G, DASHTIRAHMATABADI M H, ZANBAGH S, et al. Mumijo attenuates chemically induced inflammatory pain in mice[J] . Alternat Thera Health Med, 2015, 21(2):42-47.
[30]
TIWARI P, RAMARAO P, GHOSAL S. Effects of shilajit on the development of tolerance to morphine in mice[J] . Phytother Res, 2001, 15(2):177-179.
[31]
JANKOVI B D. Neural tissue hypersensitivity in psychiatric disorders with immunologic features[J] . J Immunol, 1985, 135(2):853-857.
[32]
BHATTACHARYA S K. Shilajit attenuates streptozotocin induced diabetes mellitus and decrease in pancreatic islet superoxide dismutase activity in rats[J] . Phytother Res, 1995, 9(1):41-44.
[33]
MOHAN L, RAO U S C, GOPALAKRISHNA H N, et al. Evaluation of the anxiolytic activity of NR-ANX-C(a polyherbal formulation) in ethanol withdrawal-induced anxiety behavior in rats[J] . Evid Based Complement Alternat Med, 2011(5):140-144.
[34]
JAISWAL A K, BHATTACHARYA S K. Effects of shilajit on memory, anxiety and brain monoamines in rats[J] . Indian J Pharmacol, 1992, 24:12-17.
[35]
DURG S, VEERAPUR V P, THIPPESWAMY B S, et al. Antiepileptic and antipsychotic activities of standardized ��il��jatu (Shilajit) in experimental animals[J] . Ancient Sci Life, 2015, 35(2):110-117.
[36]
CORNEJO A, JIM NEZ J M, CABALLERO L, et al. Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer′s disease[J] . J Alzheimers Dis Jad, 2011, 27(1):143-153.
[37]
TANIGUCHI S, SUZUKI N, MASUDA M, et al. Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins[J] . J Biol Chem, 2005, 280(9):7614-7623.
[38]
CARRASCO-GALLARDO C, FARíAS G A, FUENTES P, et al. Can nutraceuticals prevent Alzheimer′s disease? Potential therapeutic role of a formulation containing shilajit and complex B vitamins[J] . Arch Med Res, 2012, 43(8):699-704.
[39]
GHOSAL S, LAL J, SINGH S K, et al. Mast cell protecting effects of shilajit and its constituents[J] . Phytother Res, 1989, 3(6):249-252.
[40]
SHALINI, SRIVASTAVA R. Antifungal activity screening and hplc analysis of crude extract from tectona grandis, shilajit, valeriana wallachi[J] . Electr J Environ Agricul Food Chem, 2009, 8(4):218-229.
[41]
BISWAS T K, PANDIT S, MONDAL S, et al. Clinical evaluation of spermatogenic activity of processed shilajit in oligospermia[J] . Andrologia, 2010, 42(1):48-56.
[42]
PANT K, GUPTA P, DAMANIA P, et al. Mineral pitch induces apoptosis and inhibits proliferation via modulating reactive oxygen species in hepatic cancer cells[J] . BMC Compl Alternat Med, 2016, 16(1):148-148.
[43]
JOUKAR S, NAJAFIPOUR H, DABIRI S, et al. Cardioprotective effect of mumie (shilajit) on experimentally induced myocardial injury[J] . Cardiovas Toxicol, 2014, 14(3):214-221.
[44]
ACHARYA S B, FROTAN M H, GOEL R K, et al. Pharmacological actions of shilajit[J] . Indian J Exp Biol, 1988, 26(26):775-777.
[45]
KEL′GINBAEV N S, SOROKINA V A. Treatment of long tubular bone fractures with mumie assil preparations in experiments and clinical conditions[J] . Eksp Khir Anesteziol, 1973, 18(4):31-35.
[46]
STOHS S J. Safety and efficacy of shilajit(mumie, moomiyo)[J] . Phytother Res, 2014, 28(4):475-459.
2018, Vol. 53 
