Efficacy and Safety of Everolimus Combined with Endocrine Therapy for Hormone Receptor-positive Advanced Breast Cancer: A Systematic Review
PENG Jia1,2, TAN Bo-yu1, KONG Xiao-min1,2, DENG Nan1*
1. Department of Pharmacy, The First Affiliated Hospital of Hunan Normal University, Changsha 410005, China; 2. Medical College,Hunan Normal University,Changsha 410006, China
Abstract��OBJECTIVE To systematically review the effect and safety of everolimus combined with endocrine therapy for hormone receptor-positive advanced breast cancer.METHODS The randomized controlled trails (RCTs) on everolimus combined with endocrine therapy or everolimus in the treatment of endocrine failure were searched in PubMed,MEDLINE,CENTRAL,EMBASE, the Cochrane Library and CNKI from the date of their establishment to March 2017. According to the inclusion criteria,assessed the quality for the requirements of RCT and Meta analysis were performed with Rev-Man 5.3 software.RESULTS Of 518 articles collected,a total of 7 RCTs involving 1 823 patients were included. The results of Meta-analyses showed that: compared with endocrine therapy alone,everolimus combined with endocrine therapy could prolong the progression-free survival (PFS) for patients with HR+ breast cancer(HR=0.53,95%CI:0.45-0.62,P��0.001),improve the clinical benefit rate(OR=2.31,95%CI:1.49~3.59,P=0.000 2), improve the quality of life(HR=0.75,95%CI:0.60-0.94,P=0.01),but it could not improve objective response rate(OR=1.22,95%CI:0.61-2.48,P=0.57). The most common adverse effects of everolimus combined with endocrine therapy are fatigue,stomatitis,anorexia,hot flashes,rash,diarrhea,pneumonia and hyperglycemia.CONCLUSION The curative effect of everolimus combined with endocrine therapy is significantly better than endocrine therapy alone in hormone-positive breast cancer with adverse effects increased.
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PENG Jia, TAN Bo-yu, KONG Xiao-min, DENG Nan. Efficacy and Safety of Everolimus Combined with Endocrine Therapy for Hormone Receptor-positive Advanced Breast Cancer: A Systematic Review. Chinese Pharmaceutical Journal, 2018, 53(3): 228-233.
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