Abstract��Studies of blood-brain barrier (BBB) play an important role in the R&D of new drugs for neurological disorders. Cell-culture models of blood-brain barrier are helpful to study the functions and biological properties of the major BBB components, including brain microvascular endothelial cells, astrocytes, and pericytes, observe and analyze different components�� reactions during the drug treatment, optimize the dosing progress, and reduce toxicity. According to the properties of individual BBB components, we summarized several widely used in vitro models of BBB, including monolayer models, co-culture models and the newly developed microfluidic-based models. By comparing their advantages and disadvantages, we provided suggestions on the selection of BBB models according to different research purposes.
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NIE Zi-han, LI Jun-fa, ZHAO Li. Research Progress in Cell-Culture Models of Blood-Brain Barrier. Chinese Pharmaceutical Journal, 2018, 53(3): 165-168.
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2018, Vol. 53 
