Pharmacokinetic Study on Xuesaitong Dispersible Tablets and Common Tablets in Beagle Dogs in Vivo
LÜ Xiao-bo1, ZHANG Ming-ze1, HUANG Chun-qiu1, ANG Jun-ying1, WU Zheng-cai1, LIU Li2*
1. Department of Research and Development, Yunnan Phytopharmaceutical Co., Ltd, Kunming 650109, China 2. China Pharmaceutical University, Nanjing 210009, China
Abstract��OBJECTIVE To compare the pharmacokinetic parameters of Xuesaitong dispersible tablets and common tablets in Beagle dogs. METHODS Using double cycle crossover trial, six Beagle dogs were treated with single oral dose of 100 mg of Xuesaitong dispersible tablets and conventional tablets and determining the pharmacokinetic parameters of ginsenoside Rb1 and Rg1 in Xuesaitong dispersible tablets and conventional tablets in Beagle dog plasma. RESULTS The ginsenoside Rb1 and Rg1 peak concentration of Xuesetong dispersible tablets in Beagle dog plasma was significantly higher than that of Xuesaitong tablets, the ginsenoside Rg1 peak time of Xuesaitong dispersible tablets in Beagle dog plasma was significantly earlier than that of Xuesaitong tablets. Additionally, the ginsenoside Rb1 peak time exhibited ahead of the trend, which is in line with the characteristics of rapid disintegration and absorption of preparation in vivo. CONCLUSION The plasma exposure in two preparation of ginsenoside Rb1 and Rg1 in Beagle dog holds fairly basic and no significant difference. But the ��max of the main ingredients of Panax ginseng saponins Rb1 and Rg1 in Xuesaitong dispersed tablets, is significantly higher than that of the film coated tablets, and peak time is significantly shortened, which could promote the drug absorption.
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LÜ Xiao-bo, ZHANG Ming-ze, HUANG Chun-qiu, ANG Jun-ying, WU Zheng-cai, LIU Li. Pharmacokinetic Study on Xuesaitong Dispersible Tablets and Common Tablets in Beagle Dogs in Vivo. Chinese Pharmaceutical Journal, 2018, 53(1): 52-57.
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2018, Vol. 53 
